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B cells at the crossroads of autoimmune diseases

Published on October 31, 2023   42 min

Other Talks in the Series: The Immune System - Key Concepts and Questions

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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0:00
Hello everyone, I'm Lin Xiang from the School of Chinese Medicine, the University of Hong Kong. Today, I'd like to talk about the role of B cells in autoimmune diseases.
0:13
The simplified immune response against autoantigens. The B cells receive the stimulants via the B cell receptor, they then present then antigens to cognate T cells and further promote T cell differentiation by costimulatory molecules and cytokine production. Well, these B cells, however, mature into autoantibody-producing plasma cells. This cascade happens throughout the disease progression. Now, extensive studies have suggested a central role of B cells in the autoimmune pathogenesis. Because loss of B cell tolerance can result in increased serum levels of autoantibodies and enhanced effector T cell response and tissue damage in patients. Today we'll walk through the overview of these regulated B cell responses in the development of autoimmunity.
1:03
As you can see, the B cell tolerance is established throughout the B cell developmental stages in both bone marrow and the peripheral lymphoid organs. From the prob-B to pre-B cell stages, they will migrate into the periphery and then become immature B cells, through to the maturation and the differentiation stages, while part of the plasma cells will migrate back to the bone marrow through chemotaxis. Although approximately 55% to 75% of early immature B cells will exhibit self-reactivity, most of the other reactive B cells are eliminated by multiple checkpoints accordingly, which we will explain in later slides. Histopathologically, the massive B cells are detected in

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B cells at the crossroads of autoimmune diseases

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