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Printable Handouts
Navigable Slide Index
- Introduction
- Glycobiology
- Glycosylation: a highly regulated cellular process
- Glycosylation at the frontiers of inflammation and cancer
- Glycans in cancer development and progression
- Glycans in cancer immunoediting
- Colorectal cancer
- Complex branched N-glycans in colorectal cancer immunoediting
- Highly branched glycans instructors immunosuppressive networks in cancer (in vitro)
- Deletion of branched N-glycans prevents colorectal tumour development and progression (in vivo)
- Deletion of branched N-glycans prevents tumour development and progression (in vivo)
- Branched N-glycans as immune-checkpoints in colorectal cancer
- Glycans as shapers of the tumour microenvironment
- Mannosylated glycans impair normal T-cell development
- Glycome dynamics in T and B cell development: impact in disease susceptibility
- Immunology, cancer & glycomedicine group @ i3S
- Glycosylation at the frontiers of inflammation and cancer
- Glycans as evolutionary determinants in self/non-self discrimination
- Glycans as a key factor in self and non-self discrimination
- GlycoMapping of kidney biopsies from lupus nephritis (LN) patients
- Abnormal cellular mannosylation characterises LN patients
- Levels of cellular mannosylation predict the development of chronic kidney disease
- Protein mannosylation as a diagnostic and prognostic biomarker of lupus nephritis
- Cellular mannosylation as a trigger of gdT cells activation in lupus
- Aging Mgat5-/-mice develop spontaneous lupus-like syndrome
- Glycosylation reprogramming of ex vivo kidney biopsies from lupus patients
- Host-derived mannose glycans trigger a pathogenic gdT cell/IL-17a axis in autoimmunity
- Muscle glycome in idiopathic inflammatory myopathies (IMM)
- Pinho’s Lab: Immunology, Cancer & GlycoMedicine
Topics Covered
- Introduction to glycobiology and glycans
- Protein glycosylation
- Role of glycans in inflammation and cancer
- Glycans in tumour immunology
- Glycans in thymic T cell development
- Mannosylated glycans
- Glycans as essential molecules in self/non-self-discrimination
- Role of glycans in autoreactive immune responses and autoimmune disease
Links
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External Links
Talk Citation
Pinho, S.S. (2024, May 30). Glycans at the frontiers of inflammation, autoimmunity and cancer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/UVHJ8032.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Salome Pinho.
I'm the Group Leader of
the Immunology, Cancer, and
GlycoMedicine Research Group at
the Institute for Research
and Innovation in Health,
University of Porto in Portugal.
Today I'm going to talk about
the relevance and the power of
glycans at the frontiers of
inflammation,
autoimmunity, and cancer.
0:26
What about glycans, and what are
glycans in the context
of glycobiology?
Essentially, all of our
cells are covered with
this dense and complex coat
of sugar chains that
we call glycans,
forming this beautiful
layer of glycans of
sugar chains that emerge
in essentially all
cell surfaces.
These actually constitute
the glycocalyx.
Which is a major biological
and physical interface
with the micro-environment,
such as with micro-organisms
and also with
the immune system, as I'm
going to talk about today.
As stated in this science paper,
genome size cannot account for
the complexity of an organism,
and that's why the glycome
compose and constitute
a huge amount of
important biological
information that
is added to the genome
and the proteome.
Essentially, this
beautiful layer
of glycans of sugar
chains is because
the majority of our
proteins and lipids are
modified with glycans in
a process that is
called glycosylation.
We have a huge repertoire of
different glycan structures that
modify protein and
lipids but we can
also have glycans as
free oligosaccharides such as
the example of hyaluronic acid.
Glycosylation is actually