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The molecular basis of cancer metastasis: molecular mechanisms of epithelial-mesenchymal transition in tumor metastasis

Part 1 of 2
Published on April 30, 2023   30 min

Other Talks in the Series: The Molecular Basis of Cancer

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

0:00
Hello everyone. Today, my lecture's title is the molecular basis of cancer metastasis. Let's first introduce myself. My name is Jing Yang, I'm a professor at University of California, San Diego, department pharmacology and pediatrics. My lab is the Moores Cancer Center at UCSD.
0:22
First-ever like to introduce you the outline of the lecture. I will first discuss the multi-step process of tumor metastasis. Then they will spend a significant amount of time to discuss this epithelial mesenchymal transition and cellular plasticity metastasis. Then we will talk about the organ topic metastasis and how this regulation in tropism is regulated. In the end, I will have a brief discussion on how to develop therapeutics to prevent or inhibit develop of metastasis.
0:59
As you all know that although there's a lot of work had been done trying to understand the molecular basis of primary tumor formation. But what's really killing cancer patients is actually metastasis. Metastasis is a multi-step process where a primary tumor cells that initially located in this primary site become locally invasive, invaded through the basement membrane and then made it to the nearby tissue and some of the tumor cells are able to intravasate into the circulation, enter the blood and lymphatic circulation. After surviving in the circulation, they extravasated from the circulation into the distant organs and at a decent organ, some of the tumor cells are able to either adapt themselves to this new microenvironment or they actually modify this environment to make it much more friendly against to themselves that allow them to re-grow formed the secondary growth that are eventually life-threatening to the patients. Major research effort in the metastasis research is trying to understand what are the molecular and cellular programs that are activated to allow the stationary epithelial cell the ability to migrate, to invade and to actually eventually spread into a distance sites.
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The molecular basis of cancer metastasis: molecular mechanisms of epithelial-mesenchymal transition in tumor metastasis

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