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0:00
Hello everyone.
Today, my lecture's
title is the molecular
basis of cancer metastasis.
Let's first introduce myself.
My name is Jing Yang, I'm
a professor at University
of California,
San Diego, department
pharmacology and pediatrics.
My lab is the Moores
Cancer Center at UCSD.
0:22
First-ever like to introduce you
the outline of the lecture.
I will first discuss
the multi-step process
of tumor metastasis.
Then they will spend
a significant amount
of time to discuss
this epithelial
mesenchymal transition
and cellular
plasticity metastasis.
Then we will talk about the
organ topic metastasis and
how this regulation in
tropism is regulated.
In the end, I will have
a brief discussion
on how to develop
therapeutics to prevent or
inhibit develop of metastasis.
0:59
As you all know that although
there's a lot of work had
been done trying to understand
the molecular basis of
primary tumor formation.
But what's really killing
cancer patients is
actually metastasis.
Metastasis is a
multi-step process where
a primary tumor cells
that initially located in
this primary site become
locally invasive,
invaded through the
basement membrane
and then made it to
the nearby tissue and
some of the tumor cells are able
to intravasate into
the circulation,
enter the blood and
lymphatic circulation.
After surviving in
the circulation,
they extravasated
from the circulation
into the distant organs
and at a decent organ,
some of the tumor cells are able
to either adapt themselves to
this new microenvironment
or they actually
modify this environment
to make it much more
friendly against to themselves
that allow them to re-grow
formed the secondary
growth that are
eventually life-threatening
to the patients.
Major research effort in
the metastasis research is
trying to understand what are
the molecular and cellular
programs that are activated to
allow the stationary
epithelial cell
the ability to migrate,
to invade and to actually
eventually spread into
a distance sites.