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Printable Handouts
Navigable Slide Index
- Introduction
- Lecture outline
- Multi-step metastasis model
- Part I: EMT and cellular plasticity
- Epithelial cells are connected by various cell junctions
- How do carcinoma cells invade?
- Local invasion – collective invasion
- Local invasion – invasive ductal carcinoma
- Mammary terminal endbud invades stroma
- Local invasion – single cell invasion
- Local invasion – Cajal's drawings
- Local invasion – invasive lobular carcinoma
- Gastrulation
- Neural crest development
- Epithelial-Mesenchymal Transition (EMT)
- Epithelial-mesenchymal plasticity
- How is this program regulated?
- Adherens junction
- Suppression of E-cadherin during EMT
- CDH1 germline mutations in hereditary diffuse gastric cancers (1)
- CDH1 germline mutations in hereditary diffuse gastric cancers (2)
- Loss of cell adhesion in invasive lobular carcinoma
- Cell scattering and invasiveness induced by HGF
- Transcription regulation of EMT
- Snail represses E-cadherin transcription through E-boxes
- Snail in gastrulation
- Snail in neural crest development
- EMT in Drosophila mesoderm formation
- Twist is a potent inducer of EMT
- Twist is essential for breast tumors to metastasize
- EMT: molecular markers summary
- Invadopodia: specialized structures for matrix degradation
- Twist-induced invadopodia is functional in ECM degradation
- Transcription regulation of EMT: main families
- Transcription regulation of EMT: cancer associations
Topics Covered
- Multi-step metastasis model
- Epithelial derived carcinoma
- Collective invasion
- Drosophila gastrulation
- Xenopus neural crest formation
- Epithelial-mesenchymal transition (EMT)
Links
Series:
- The Molecular Basis of Cancer
- Periodic Reports: Advances in Clinical Interventions and Research Platforms
Categories:
Therapeutic Areas:
Talk Citation
Yang, J. (2023, April 30). The molecular basis of cancer metastasis: molecular mechanisms of epithelial-mesenchymal transition in tumor metastasis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 14, 2024, from https://doi.org/10.69645/LWAU2642.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jing Yang has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The molecular basis of cancer metastasis: molecular mechanisms of epithelial-mesenchymal transition in tumor metastasis
Published on April 30, 2023
30 min
Other Talks in the Series: The Molecular Basis of Cancer
Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms
Transcript
Please wait while the transcript is being prepared...
0:00
Hello everyone,
Today, my lecture's title is
The Molecular Basis
of Cancer Metastasis.
Let me first introduce myself.
My name is Jing Yang.
I'm a professor at
the University of
California San Diego,
Department of Pharmacology
and Pediatrics.
My lab is at the Moores
Cancer Center at UCSD.
0:22
First, I would like
to introduce you to
the outline of the lecture.
I will first discuss
the multi-step process
of tumor metastasis.
Then I will spend a
significant amount of time
to discuss this
epithelial-mesenchymal transition
and cellular plasticity
in metastasis.
Then we will talk about
organ-tropic metastasis and
how dysregulation in
tropism is regulated.
In the end,
I will have a brief discussion
on how to develop
therapeutics to
prevent or inhibit the
development of metastasis.
0:59
As you all know,
there has been a lot of work
that has been done,
trying to understand
the molecular basis of
primary tumor formation.
But what's really killing
cancer patients is
actually metastasis.
Metastasis is a
multi-step process where
a primary tumor cell set
initially located in
this primary site becomes
locally invasive,
invades through the
basement membrane,
and then makes it to
the nearby tissue.
Some of the tumor cells are
able to intravasate
into the circulation,
enter the blood and
lymphatic circulation.
After surviving in
the circulation,
they are extravasated
from the circulation
into the distant organs.
At the distant organ,
some of the tumor cells are able
to either adapt themselves to
this new microenvironment or
they actually modify
this environment
to make it much more
friendly to themselves.
That allows them to
re-grow to forme
the secondary growths that are
eventually life-threatening
to the patients.
Major research efforts in
the metastasis research
is trying to understand
the molecular and
cellular programs
that are activated to allow
the stationary epithelial cells
to have the ability to migrate,
to invade, and eventually
spread to a distant site.
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