Registration for a live webinar on 'Neuroleptic malignant syndrome' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Dendritic cells: A brief history
- Dendritic cells: Bridging innate and adaptive immunity
- The monocyte: A progenitor of dendritic cells
- Dendritic cells differentiate via either the myeloid or lymphoid pathways
- Classification of dendritic cell subsets
- Plasmacytoid dendritic cells
- Type I interferons in innate and adaptive immunity
- Conventional dendritic cells
- Mechanisms of antigen acquisition
- Antigen processing via the endocytic pathway
- Division of labour between DC subsets
- cDC1 dendritic cells are responsible for cell mediated immunity
- Mechanisms of antigen cross-presentation
- Dendritic cell maturation
- Dendritic cell migration
- Signals for naïve T cell activation
- The immunological synapse
- Dendritic cells guide T cell commitment
- The outcomes of DC-T cell interactions
- Homeostatic expansion: Proliferation without activation
- The thymus: A site of central tolerance
- Clonal deletion of self-reactive thymocytes
- The quest for a subset of tolerogenic DCs
- Induction of Treg cells
- Mechanism of action of Treg cells
- Therapeutic use of dendritic cells
- Cancer immunotherapy
- Clinical trials of cancer immunotherapy
- Induction of tolerance in a clinical context
- Summary
Topics Covered
- Differentiation of dendritic cells from hematopoietic progenitors
- Classification of dendritic cell subsets
- Dendritic cell maturation and migration patterns
- Outcomes of DC-T cell interactions
- The therapeutic use of dendritic cells
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Fairchild, P.J. (2021, April 28). Dendritic cells: professional antigen presenting cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/DHQW3623.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Fairchild is a deputy editor of the Journal of Immunology and Regenerative Medicine. He also receives grants from the UCSF, Rosetrees Trust and EPA Trust. He has two patents licensed by OxVax Ltd. He has shares in OxVax Ltd as Founding Director.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Paul Fairchild and I'm based at the Sir William Dunn School of
Pathology at Oxford University, where I'm also a fellow of Trinity College.
What I want to do is to give you a broad overview in this lecture of
a particular cell type which is absolutely crucial to the immune system,
and that is, of course, the dendritic cell.
The reason that dendritic cells are so critical
to the immune system is that all immune responses,
whether protective or pathogenic in their own right,
are initiated by the presentation of antigen to naive T-cells by dendritic cells.
But dendritic cells are also a cell type which is very close to my own heart
because I first encountered them as a PhD student back in the late 1980s,
and I've been studying their properties, on and off, pretty much ever since.
I've spent many happy hours in the presence of dendritic cells.
0:54
Let me begin by giving you a little historical perspective.
Dendritic cells were first discovered back in the early 1970s by Ralph Steinman and
Zanvil Cohn as a unique population of
leucocytes in the spleens and the lymph nodes of mice.
It was that observation which earned
Ralph Steinman the Nobel Prize for Medicine or Physiology back in 2011,
which was something of a bitter-sweet award.
He sadly died just two days before the award was announced,
and so never knew that he'd been awarded the Nobel Prize.
Nevertheless, his name will always be associated with
dendritic cells, and his contribution to immunology will always be acknowledged.
He was the first to call these cells
dendritic cells in recognition of their very complex morphology,
but also to reflect the fact that they can interdigitate among
naive T-cells in the secondary lymphoid tissues to form quite complex clusters of cells,
and you can see some of these in this photomicrograph.
Although he worked with Zanvil Cohn, particularly on macrophages,
it soon became clear that dendritic cells can be
distinguished from macrophages on a number of different bases.
First of all they constitutively express MHC class II molecules, but more importantly,
they have the unique capacity to stimulate antigen-naive T-cells
in an assay which has since become known as the 'mixed leukocyte reaction'.
Macrophages in that same assay fail completely to
stimulate naive T-cells, and fail to induce their proliferation.
Dendritic cells are unique when measured via the mixed leukocyte reaction.
Although dendritic cells were first discovered as
that population in the secondary lymphoid tissues of mice,
they were subsequently found to be distributed throughout
all interstitial tissues and peripheral organs of the body in an immature form,
where they serve as 'sentinels' of the immune system.
They have that capacity to sense the presence of
infectious microorganisms within the local vicinity.
Quite how these cells in peripheral tissues are related to the cells originally
identified by Ralph Steinman in
the secondary lymphoid tissues has only become clear in recent years,
but it's a journey of discovery that has helped us understand how
these cells help to bridge so effectively, innate and adaptive immunity.
The ability of dendritic cells to span these two arms of