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Printable Handouts
Navigable Slide Index
- Introduction
- Definitions for organ transplantation
- Other definitions
- Which donor antigens can trigger rejection?
- Human Major Histocompatibility Complex
- Tissue typing
- Crossmatching
- The immune responses to an allograft (1)
- Rejection
- Innate immunity or natural immunity
- Innate immunity sets the stage
- The innate response does not act alone
- Innate immune system: physiological role (1)
- Innate immune system: physiological role (2)
- Pattern recognition receptors
- Graft injury activates the innate immunity
- Characteristics of a typical phagocytic cell
- Pathways of complement activation
- Leukocyte adhesion cascade
- Impact of graft injury
- Innate immune responses: cells & molecules
- Innate & adaptive immune responses (1)
- The adaptive immune response
- Every organ contains passenger leukocytes
- Passenger leukocytes during transplantation
- Dendritic cells interact with T cells
- Recognition triggers rejection
- Rejection: activated T cells talk to B cells
- Rejection: B cells play a central role
- Antibody: Immunoglobulin IgG
- Impact of antibody & complement on EC (1)
- Other pathways of complement activation
- Impact of antibody & complement on EC (2)
- Pathways of antibody-mediated damage to EC
- Impact of antibody & complement on EC (3)
- Impact of antibody & complement on EC (4)
- B cells play multiple roles in graft rejection
- The immune responses to an allograft (2)
- Innate & adaptive immune responses (2)
- Rejection of solid organ transplants
- Bone marrow & HSC transplantation
- Evolution of Graft vs. Host Disease (GVHD)
Topics Covered
- Organ Transplantation
- Immunology
- Definitions of Organ Transplantation
- Major Histocompatibility Complex
- Graft vs. Host Disease
- Tissue Typing
- Crossmatching
- Graft Injury
- Bone Marrow Transplantation
- Hematopoietic Stem Cell Transplantation
Links
Series:
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Therapeutic Areas:
Talk Citation
Wood, K. (2021, September 29). Principles of transplantation: overview of the immune response [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/WWST3477.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Emerita Kathryn Wood has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
A warm welcome to everybody participating in
this lecture today, where we're going to discuss the principles of transplantation.
My name is Kathryn Wood, I'm Professor Emerita of immunology at the University of Oxford,
where I work in the Nuffield Department of Surgical Sciences, alongside the transplantation team.
0:22
A few definitions around transplantation - both solid organ transplantation
and bone marrow, or haematopoietic stem cell, transplantation -
just to orientate ourselves and get us started on this lecture.
In organ transplantation there are a number of different ways a transplant can
be performed, between a donor and a recipient.
The first, shown at the top of the slide, is an 'autograft', where tissue is
taken from the same individual, and re-implanted after a surgical procedure.
The second option, which is similar (but not necessarily the same thing) is called an 'isograft',
where tissue from the individual is taken, stored, and re-implanted at a later date.
The most common option in terms of organ transplantation for organ failure is
so-called 'allografting', or transplantation between individuals that are not genetically identical,
that's shown in the third line of this definition slide.
You can see I've tried to illustrate that by showing a transplant occurring from a blue donor
into a red recipient.
In this case, it's the recipient's immune system that responds to the organ that has been transplanted.
The final element of this slide is 'xenotransplantation' or 'xenografting',
where an organ is taken from a different species and transplanted into a host.
The most common approach that's being investigated experimentally at the moment
in this context is where pig organs, genetically modified in most cases, are being investigated as
potential sources of donor organs for human transplantation in the future.
However, this is still very much at an experimental stage, and not used for clinical transplantation at present.
In bone marrow transplantation, or haematopoietic stem cell transplantation, the opposite is true;