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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Lymphocytes and antigen receptors
- T cell receptor gene rearrangement and structure
- T cells see many different types of foreign or abnormal molecules (antigens)
- Section 1: CD1-lipid Ag reactive T cells
- CD1-lipid Ag presentation
- Natural Killer T (NKT) cells
- Conventional T cells vs NKT cells
- What glycolipid antigens do NKT cells see?
- Other types of CD1 restricted T cells
- Section 2: Mucosal associated invariant T (MAIT) cells
- T cells see many different types of antigens: MAIT cells
- Mucosal associated invariant T (MAIT) cells
- MAIT cells recognise MR1-binding vitamin B metabolites
- Many, but not all, bacteria, and all yeast, activate MAIT cells
- MRI-5-OP-RU tetramers specifically detect MAIT cells (1)
- MRI-5-OP-RU tetramers specifically detect MAIT cells (2)
- MAIT TCR contacts both MR1 and antigen
- Section 3: γδ T cells
- T cells see many different types of antigens: γδ T cells
- Different γδ T cells, based on which TCR-δ genes they use
- Phosphoantigens
- How do γδ T cells sense phosphoantigen?
- Vδ2 γδ T cells detect phosphoantigen via butryophilins 3A1 and 2A1
- In summary
- Acknowledgments
Topics Covered
- CD1-lipid antigen reactive T cells
- Mucosal-associated invariant T (MAIT) cells
- γδ T cells
- Antigen receptors
- T cell receptor structure
- Natural killer T (NKT) cells
- Vitamin B metabolites
- Phosphoantigens
- Butryophilins
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Godfrey, D. (2023, March 30). Unconventional T cells: a major component of the human immune system with untapped therapeutic potential [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/UQPY8958.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Godfrey is a member of the scientific advisory board for Avalia Immunotherapies, and he holds several provisional patent applications in the area of unconventional T cell biology.
Unconventional T cells: a major component of the human immune system with untapped therapeutic potential
Published on March 30, 2023
45 min
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
Thank you for the invitation
to give a talk in this series.
My name is Professor
Dale Godfrey.
I work in the department
of microbiology and
immunology at the Peter
Doherty Institute
at the University of Melbourne.
This talk's entitled
unconventional T-Cells:
A major component of the
human immune system with
untapped therapeutic potential.
0:21
The talk is really intended
to be a bit of a primer
about three different classes
of unconventional T-cells.
There's a huge amount
of literature about
these cells and I'm
not going to be
able to go into great detail,
but it hopefully will represent
a good starting point to get
an understanding of some of
the complexity of human
T lymphocytes that
extends beyond your classical
CD4 and CD8 T-cells.
0:47
Just to gently introduce
these cells in the context
of the immune system,
a major component in
the immune system,
are the lymphocytes and
these cells have
antigen receptors.
Lymphocytes recognize
infections based on
foreign molecules,
which we know of as antigens.
Each lymphocyte carries a
unique antigen receptor.
There are so many different
antigen receptors
that theoretically
there's up to 10 to
the 18 different types
of antigen receptor.
This means that the
lymphocytes are capable of
recognizing the universe of
possible antigens, essentially.
Now, there are two different
broad classes of lymphocytes.
There are the
B-cells and T-cells.
They both have antigen receptors
but the receptors are different.
B-cells have antigen receptors
made out of surface
immunoglobulin,
which is basically
surface antibody.
When these cells are activated,
they turn into plasma
cells and they begin to
secrete those receptors
as antibodies,
which is what we all have
flowing in our blood.
Then there are the
T-cell receptors,
these are different
from antibodies.
They membrane-bound only,
they are not secreted,
but they also are highly
diverse and give the
T-cells the ability to
recognize the universe of
different types of antigens
that T-cells might encounter.
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