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Printable Handouts
Navigable Slide Index
- Introduction
- CD8 T cells
- Two main T cell subsets: CD4 and CD8
- Two main T cell subsets: antigens
- T cell activation: signal 1 and 2
- T cell activation: signal 3
- T cell response: graph
- T cell response: illustration
- T cell memory: areas of interest
- T cell memory: cell markers
- Tissue resident memory T cells in situ
- T cell memory persists in skin after infection
- TRM cells scan the epithelial barrier after infection has been cleared
- TRM scan only within their tissue compartment
- How do TRM cells develop?
- How do TRM cells develop?: model
- Summary
- TRM cells: start of a immune response
- TRM cells: continuation of the immune response
- TRM cells: after the immune response
- TRM cell transcription factors: two unique transcription factors
- TRM cell transcription factors: expression in different tissues
- TRM cell development: absence of TGFb
- TRM cell development: regulatory T cells
- TRM cell development: Foxp3
- TRM cell function: model systems
- TRM cell function: Rag2 knockout
- TRM cell function: Foxp3
- Memory CD8+ T cells protect against malaria
- TRM cell function: airway resident memory cells
- TRM cell function: tumor therapy properties
- TRM cell function: immunotherapies
- Aberrant TRM cell roles: autoimmunity diseases
- Aberrant TRM cell roles: coeliac disease
- Aberrant TRM cell roles: vitiligo
- Concluding remarks
Topics Covered
- T cell activation
- T cell response
- T cell memory
- Tissue Resident Memory T cells (TRM)
- TRM cell development
- TRM cell transcription factors
- TRM cell function
- Aberrant TRM cell roles
Links
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Therapeutic Areas:
External Links
Talk Citation
Veldhoen, M. (2022, July 25). Tissue resident memory T cells (TRM) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 10, 2024, from https://doi.org/10.69645/VXYF8328.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Marc Veldhoen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
Good day.
My name is Marc Veldhoen.
I'm a professor of immunology at
Lisbon University in Portugal.
Today's subject is tissue
resident memory cells.
We will get a closer look
at how they are defined,
how they develop, and
what uses they have.
0:16
I'm going to limit
myself to CD8 T cells.
These are the most defined
tissue resident memory cells.
These are the cells that
provide protection against
infections by
intracellular pathogens.
The most common are
viruses and bacteria,
but also protozoan parasites.
Think about the
malaria parasite.
Lastly, and not unimportantly,
they also provide
protection against tumours.
We will go into that
a little bit later.
0:41
There are two main
T cell subsets,
CD4 T cells and CD8 T cells.
Importantly, CD8 T
cells get antigens
presented to them in
MHC class I molecules,
that's how they get activated.
CD4 T cells get
presented through the
antigens in MHC
class II molecules.
0:60
The two main T cell subsets pick
up antigens from
different cell types.
Any cell in your body
expresses MHC class I
because every cell in your
body can get infected.
These can be recognised
by CD8 T cells.
CD4 T cells get presented
when things are eaten
by antigen-presenting (APCs).
These constantly eat, bounce
off their environment
and present themselves
before T cells.
Now, I'm going to
focus on CD8 T cells,
but CD4 T cells will
play a role because they
are really the orchestrators
of immune responses.
1:35
Just a reminder that,
during an activation,
a T cell needs several signals.
Otherwise, nothing will happen.
The interaction between
an MHC molecule,
a peptide and a T-cell receptor
does not result in activation.
This would be too dangerous,
you will need more signals.
Signal 2 comes from
co-stimulatory molecules,
of which there are
a whole bundle.
We will not go into
that today at all.
That results in the
stabilisation of the signal
and proliferation of T cells.