Building implantable human liver tissue from pluripotent stem cells

Published on May 31, 2023   34 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

Other Talks in the Series: Stem Cells

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Hi, my name is David Hay. I'm Professor of Tissue Engineering at the University of Edinburgh's Centre for Regenerative Medicine. Today, I'm gonna talk about "Building Implantable Human Liver Tissue from Pluripotent Stem Cells".
I have a couple of disclosures before we go any further. I'm founder, director and shareholder of Stemnovate Limited based in Cambridge, UK.
I'm also founder, CEO, and shareholder in Stimuliver, a company based in Copenhagen at the BioInnovation Institute.
Our interest is in the liver and the liver is a highly organised organ. It's comprised of four lobes. Each of those lobes has an organised lobule structure. This organisation of the lobule structure is essential for the liver's multifunctional capacity, which has been estimated to have over 500 functions within the body and also, this is very important for liver regeneration when the liver is damaged. What we see happening in the disease process is the gradual breakdown of this lobule structure. This leads to loss of liver function, loss of liver regeneration, and can lead to the onset of liver disease.
What does liver disease look like in the UK? This is a growing disease and a growing concern, where we see some major causes of death decrease or stabilise over the last 50 years, liver disease has increased fourfold, and this is why I'm interested in studying liver disease to try and find ways to understand the disease process in more detail, and to try and find ways to reverse the disease process. Amid model liver biology in the dish and more recently our generating implantable tissue for liver disease patients in the clinic in the future.

Building implantable human liver tissue from pluripotent stem cells

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