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0:00
Hi, my name is David
Hay. I'm Professor of
Tissue Engineering at the
University of Edinburgh's
Centre for
Regenerative Medicine.
Today, I'm gonna
talk about "Building
Implantable Human Liver Tissue
from Pluripotent Stem Cells".
0:16
I have a couple of disclosures
before we go any further.
I'm founder, director
and shareholder of
Stemnovate Limited
based in Cambridge, UK.
0:26
I'm also founder, CEO,
and shareholder in Stimuliver,
a company based in
Copenhagen at the
BioInnovation Institute.
0:36
Our interest is in the liver and
the liver is a highly
organised organ.
It's comprised of
four lobes. Each of
those lobes has an
organised lobule structure.
This organisation of
the lobule structure is
essential for the liver's
multifunctional capacity,
which has been estimated to have
over 500 functions within
the body and also,
this is very important for
liver regeneration when
the liver is damaged.
What we see happening
in the disease process
is the gradual breakdown
of this lobule structure.
This leads to loss
of liver function,
loss of liver regeneration, and
can lead to the onset
of liver disease.
1:19
What does liver disease
look like in the UK?
This is a growing disease and
a growing concern, where we see
some major causes of
death decrease or
stabilise over the
last 50 years,
liver disease has increased
fourfold, and this is
why I'm interested in
studying liver disease to try
and find ways to understand
the disease process
in more detail,
and to try and find ways to
reverse the disease process.
Amid model liver biology
in the dish and
more recently our
generating implantable
tissue for
liver disease patients in
the clinic in the future.