I'm Siamon Gordon and I work at the Sir William Dunn School of Pathology in Oxford.
Welcome to my talk, this will be part two of
the mononuclear phagocyte system which deals with tissue
recruited macrophages activation and regulation and part
1 dealt with tissue resident macrophages and their distribution and functions.
I'd like to just describe broadly the role of macrophages in human diseases.
First of all, genetically there are
lysosomal storage diseases such as Gaucher's disease and others,
in which due to enzyme deficiencies for example a substrate accumulates,
or enzymes accumulate or they form,
they can't be degraded properly.
Metabolic diseases include atherosclerosis, diabetes,
inflammatory conditions will include the dust diseases,
pneumoconiosis, silicosis, asbestosis.
Infection, of course, is very important,
not only bacterial infections such as tuberculosis and legionnaires disease,
but also HIV infection and I'll deal with some of that later on.
Autoimmune diseases like rheumatoid arthritis features,
the macrophages play a very prominent role in cartilage and bone erosion.
Degenerative diseases in the nervous system for example,
Alzheimer's disease and in the lung,
emphysema are important fibrosis important aspects of tissue repair.
In neoplastic diseases, of course,
macrophage is an important part as
tumour-associated macrophages and cancer stroma and myeloma,
for example directly mesothelioma, the asbestos-induced disease.
They play a particularly important role in chronic inflammation although they
also contribute to acute inflammation together
with neutrophils platelets and other elements.