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Printable Handouts
Navigable Slide Index
- Introduction
- Contents
- Glycobiology: a science of sugars
- Glycans have spatial and temporal diversity
- Summary of functions of glycans
- The big picture: glycan recognition
- Glycans and the immune system - study model to understand the role of glycans
- How does glycosylation relate to the immune system?
- The immune system
- Glycans and the immune responses
- Human IgG N-glycosylation
- Glycans affect the function of T cell receptors and serve to modulate intracellular signaling
- Glycans modulate the function of toll-like receptors, DC-SIGN and MHC molecules
- Glycan-binding proteins (lectins) - types and their roles in immunology
- Animal lectins and immune responses
- Mannose receptors mediate phagocytosis of micro-organisms by macrophages
- Siglecs recognize sialic acid containing glycans most inhibit cell reactivity
- Selectins: role in the tethering of circulating leukocytes to activated endothelium
- What about the immune response in congenital disorders of glycosylation?
- The immunological consequences of genetic defects associated with glycosylation (CDG)
- What are the immunological consequences of altered glycosylation in cancer?
- Sialyl Tn-expressing cancer cells
- Conclusions
Topics Covered
- Glycosylation
- Glycans and the immune system
- Different types of lectins
- The role of lectins in immunology
- Glycoimmunology in congenital disorders of glycosylation
- Glycoimmunology in cancer
Talk Citation
Videira, P. (2022, April 28). Glycoimmunology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/ZNHV9092.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Paula Videira has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
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0:00
Hello. My name is Paula Videira.
I'm a Professor at NOVA School
of Science and Technology
and also a researcher at UCIBIO, the
Institute for Health and Bioeconomy.
I'm here to give you a talk
about glycoimmunology.
Glycoimmunology has been
a science that has been
inspiring me for many years.
I'm leading a group,
a research group, which
studies glycoimmunology.
0:26
In the context of my talk,
I will start by talking
about what glycosylation is.
What are the glycans and how do
they affect the immune system.
I'll also talk about
glycan-binding proteins,
in particular lectins,
their types and their roles
in the immune response.
At the end, I will give
you some insight into how
glycoimmunology is
important for diseases
where you can find alterations
of the glycan landscape,
like in the case of congenital
disorders of glycosylation
and also in cancer.
1:01
What is glycoimmunology?
Glycoimmunology comes
from glycobiology.
It's how glycobiology
affects the immune response.
Let's talk about what
glycobiology is.
Glycobiology is the
science of sugars.
The name 'glyco' comes
from the Greek word,
glukús, and it means sweet.
This is the science of sweets,
the science of sugars.
When we say sugars or glycans,
we are talking about
the same thing.
When we take a look
at any living cells,
we will find that
these living cells
are covered by a dense
array of glycans,
like an M&M sweet.
In the beginning,
scientists thought that
the glycans on the
cell surface was merely a
shield to protect cells
and enable them to
become more robust.
But we know that there
is a huge diversity
of these glycans at
the cell surface
and that they have many
more functions attributed,
which I will talk
about later on.
Also, you can see
here in the figure,
you can see an image of
the SARS-CoV-2 virus.
This is an example, it
could be any other virus,
but you will find that
this virus is also covered
with proteins and these
proteins are glycosylated.
Take the example of
the spike protein,
which, as you know,
is very important for infection
via the SARS-CoV-2 virus.
The protein is very well decorated
with a dense array of glycans.
Another example could
be cancer cells,
like any living cells,
as I mentioned,
are covered by a dense
array of sugars.
When we look at
the cell surface,
we will find this
dense array of sugars.