The Role of Immunoglobulin Superfamily Domains and Interactions of Immune Cells.
My name is Neil Barclay,
and I've been working at the Sir William Dunn School of Pathology for many years,
and the theme of my work has been,
what happens at the surface of leukocytes,
and one of the most important families of
proteins are those that contain IgG set domains,
and that's going to be the focus of this presentation.
But first we're going to talk a little bit about what leukocytes do and what
are the types of functions we're trying to explain in molecular terms.
The key thing about leukocytes is that they interact with
lots of different cell surfaces and soluble proteins,
and what they have to do obviously is to be able to see
new pathogens or indeed old ones and respond to them.
But it's much more to it than just recognize them.
You have to get the optimal response,
you want to have the right strength,
you want to have it in the right place,
and at the right time.
You can see just a bite on the leg,
you want very localized response,
whereas with influenza, you have to pull out all the stops.
Some very different responses.
We don't want any side reactions,
auto-immune disease is obviously
a common problem where the immune system doesn't quite get it right,
and ideally you'd like to be prepared for the next infection
and you have a phenomenon of immunological memory.
What are immunoglobulin superfamily domains?
I'm going to explain a bit about what domains actually are,
I'm going to talk about how they were discovered to give a little bit of
background history into domains and IgSF domains.
What are the particular structural features of these domains?
How do they interact?
How do they carry out their function?
Also I am going to talk a little bit about why they're evolving so fast
and also what do these proteins do outside the immune system.