Share these talks and lectures with your colleagues
Invite colleaguesWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login
or review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Self-tolerance: a definition
- Why understand tolerance mechanisms?
- Knowledge of self-tolerance
- Why do we not react to self?
- Self-tolerance is acquired rather than inherited
- Classical transplantation tolerance
- Central tolerance by clonal deletion
- Central tolerance
- T-cell tolerance
- What constitutes a self-antigen for T-cell tolerance?
- T-cell tolerance in the thymus
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
- Regulatory T-cells
- Ipex syndrome
- Two major sets of CD4+ regulatory T-cells
- Role of thymus in T-cell development
- Evidence for clonal deletion in B-cells
- Peripheral tolerance
- Peripheral tolerance in T-cells
- Overview
- Co-stimulation
- Co-inhibition
- Lack of co-stimulation can result in tolerance
- Short-term co-receptor or co-stimulation blockade can promote tolerance
- Inter T-cell co-operation/Licensing of dendritic cells
- Lack of inter T-cell co-operation promotes tolerance induction
- Outcomes to tolerant cells
- Mechanisms learned from experimental tolerance induction in “adult” mice
- Tolerance to (danger-free) human gamma globulin in mice
- High dose and low dose tolerance
- B-cells stay unresponsive as long as T-cells remain tolerant: helplessness
- Autoimmune diseases
- How may tolerance “fail”
- T-cell bypass (for some autoimmune diseases)
- Coreceptor blockade to induce tolerance to foreign proteins in mice
- Non depleting CD4 and CD8 antibodies produce tolerance
- The foxp3 gene is needed for tolerance in TCR transgenic mice
- TGFβ signalling in T-cells is required for transplant tolerance through blindfolding
- Tolerance depends on constant vigilance by Foxp3+ Treg
- Tolerised mice show linked-suppression
- Tolerance through co-receptor blockade is dominant and infectious
- Decommissioning of dendritic cells by regulatory T-cells
- Acquired tissue privilege
- Modern immunosuppression: tipping the balance
Topics Covered
- Introduction to self-tolerance
- Molecular basis of tolerance
- Central and peripheral tolerance
- Autoimmune diseases
- Co-stimulation and co-inhibition
- Experimental tolerance induction
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Waldmann, H. (2020, October 29). Self-tolerance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 25, 2021, from https://hstalks.com/bs/4432/.Publication History
Financial Disclosures
- Herman Waldman has ownership interests in the Absolute Antibody company.
Self-tolerance
Published on October 29, 2020
33 min