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Printable Handouts
Navigable Slide Index
- Introduction
- Overview of lecture - introduction
- Leukocytes – the challenge
- Leukocyte recognition
- Immunoreceptors
- Immunoreceptor (NTR) signalling module
- Immunoreceptor signalling
- Examples of immunoreceptors
- Association of NTRs with shared adaptor subunits
- Overview of lecture - immunoreceptor triggering
- Immunoreceptor triggering: the example of the TCR
- Phosphorylation of TCR ITAMs is dynamically regulated
- Size of TCR vs. other cell surface molecules
- Kinetic-segregation model of TCR triggering
- Verified predictions of the model
- Distribution of CD45 and TCR
- Most NTRs are triggered by this kinetic-segregation model
- NTRs tested use the KS mechanism
- Other immunoreceptor (NTR) triggering mechanisms
- Alternate NTR triggering mechanisms: Induce proximity/aggregation
- Role of TCR 'coreceptors'
- Mechanisms of coreceptor function
- Alternate NTR triggering mechanisms: conformational change
- Conformation change in the cytoplasmic domains
- Overview of lecture - signal integration between immunoreceptors
- Signal integration in leukocyte recognition
- Immunoreceptor signalling motifs
- Types of signalling integration
- Inhibitory immunoreceptors in immune recognition
- NK cells detect changes in the ratio of inhibitory vs. activatory ligands
- Immunoreceptor receptor/ligand complexes span a similar distance
- Optimal inhibition of activatory requires matched size of ligands
- Similar receptor/ligand dimensions enables colocalization and signal integration
- Optimal inhibition requires matched sizes and colocalization
- Membrane-proximal signal integration
- Signal integration between TCR and costimulatory receptors
- TCR and some CD28 signals integrate in the nucleus
- Key ideas
- Overview of lecture – paired immunoreceptors
- Paired activatory and inhibitory immunoreceptors
- Most immunoreceptor families have paired receptors
- Activatory and inhibitory receptor pairs
- Conclusions
- Acknowledgments
Topics Covered
- Introduction to immunoreceptors
- Immunoreceptor signalling
- Immunoreceptor triggering
- Signal integration between immunoreceptors
- Paired immunoreceptors
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Talk Citation
van der Merwe, A. (2020, November 30). Immunoreceptors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 25, 2021, from https://hstalks.com/bs/4465/.Publication History
Financial Disclosures
- Prof. Anton van der Merwe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Immunoreceptors
Published on November 30, 2020
38 min