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1. Introduction
2. Overview of lecture - introduction
3. Leukocytes – the challenge
4. Leukocyte recognition
5. Immunoreceptors
6. Immunoreceptor (NTR) signalling module
7. Immunoreceptor signalling
8. Examples of immunoreceptors
9. Association of NTRs with shared adaptor subunits
10. Overview of lecture - immunoreceptor triggering
11. Immunoreceptor triggering: the example of the TCR
12. Phosphorylation of TCR ITAMs is dynamically regulated
13. Size of TCR vs. other cell surface molecules
14. Kinetic-segregation model of TCR triggering
15. Verified predictions of the model
16. Distribution of CD45 and TCR
17. Most NTRs are triggered by this kinetic-segregation model
18. NTRs tested use the KS mechanism
19. Other immunoreceptor (NTR) triggering mechanisms
20. Alternate NTR triggering mechanisms: Induce proximity/aggregation
21. Role of TCR 'coreceptors'
22. Mechanisms of coreceptor function
23. Alternate NTR triggering mechanisms: conformational change
24. Conformation change in the cytoplasmic domains
25. Overview of lecture - signal integration between immunoreceptors
26. Signal integration in leukocyte recognition
27. Immunoreceptor signalling motifs
28. Types of signalling integration
29. Inhibitory immunoreceptors in immune recognition
30. NK cells detect changes in the ratio of inhibitory vs. activatory ligands
31. Immunoreceptor receptor/ligand complexes span a similar distance
32. Optimal inhibition of activatory requires matched size of ligands
33. Similar receptor/ligand dimensions enables colocalization and signal integration
34. Optimal inhibition requires matched sizes and colocalization
35. Membrane-proximal signal integration
36. Signal integration between TCR and costimulatory receptors
37. TCR and some CD28 signals integrate in the nucleus
38. Key ideas
39. Overview of lecture – paired immunoreceptors
40. Paired activatory and inhibitory immunoreceptors
41. Most immunoreceptor families have paired receptors
42. Activatory and inhibitory receptor pairs
43. Conclusions
44. Acknowledgments

Topics Covered

• Introduction to immunoreceptors
• Immunoreceptor signalling
• Immunoreceptor triggering
• Signal integration between immunoreceptors
• Paired immunoreceptors

Links

Series:

• The Immune System - key concepts and questions

Categories:

• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on November 30, 2020

Financial Disclosures

• Prof. Anton van der Merwe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.