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Printable Handouts
Navigable Slide Index
- Introduction
- Osteoporosis: three millennia
- WHO definition of osteoporosis
- Epidemiology and health impact of osteoporosis
- Osteoporosis in Europe
- Impact of osteoporosis-related fractures
- Impact of osteoporosis-related fractures in UK
- Costs of fracture: EU27, 2010
- Survival after osteoporotic fracture
- Incidence of osteoporotic fractures
- Fracture frequency in clinical practice
- Days in hospital, rehabilitation or nursing home
- % of total healthcare allocated to fractures
- The availability of BMD varies by country
- Prevalence of osteoporosis in the EU
- Treatment gap of women by country
- Geographic variation in fracture incidence
- Worldwide variation in hip fracture incidence
- Variation in hip fracture incidence: Europe
- Vertebral fracture: semi-quantitative grading
- Distribution of vertebral fractures
- Outcome of vertebral fracture
- Prevalence of vertebral deformity
- Incidence of vertebral fracture
- Temporal trends in fracture incidence
- Global projections for hip fracture
- Secular trends in the incidence of hip fracture
- North American and European populations
- Age-adjusted incidence rate for hip fracture
- Trends in hip fracture incidence in Canada
- Hospital discharge rates for hip fracture
- Reversal of hip fracture secular trend in Belgium
- Secular trends in hip fracture worldwide
- Factors in secular trends in hip fracture
- Age / bone mass plot (men and women)
- Risk factors during adult life
- Risk factors during development
- Developmental origins of chronic disease
- Maternal vitamin D and childhood bone mass
- Maternal vitamin D and skeletal development
- Preventive strategies: high-risk approach
- “Capture the Fracture” IOF campaign
- CTF best practice framework standards
- CTF global experience Sept 2014
- Conclusions
- Thank you
Topics Covered
- Overview of osteoporosis
- Impact of osteoporosis related fractures
- Prevalence and treatment of osteoporosis related fractures
- Vertebral fractures and osteoporosis
- Trends in incidence of hip fractures
- Fracture risk factors in adulthood
- Fracture risk factors in childhood and development
- "Capture the Fracture" IOF campain
Talk Citation
Cooper, C. (2015, January 19). Epidemiology of osteoporosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/CRXA7909.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Cyrus Cooper, Lecture fees and consulting honoraria from Amgen, Danone, Eli Lilly, Procter & Gamble, Aventis, GSK/Roche, MSD, Nestle, Novartis, Nycomed, Pfizer, Servier and Wyeth, Pharmaceuticals.
Other Talks in the Series: Bone in Health and Disease
Transcript
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0:00
The Epidemiology of Osteoporosis,
Professor Cyrus Cooper, professor
of rheumatology and director,
MRC Lifecourse Epidemiology
Unit, University of Southampton
and professor of
musculoskeletal science,
University of Oxford in the UK.
0:15
Osteoporosis has been
recognized throughout antiquity.
In the left hand, bottom
corner of this slide
you see a radiograph of a section
of spine removed from a Saxon barrow
in the 8th century, and
you see quite clearly
that there's a vertical
compression fracture.
Such fractures were reported by
Hippocrates more than 400 years
before Christ and have been
reported throughout antiquity.
In the 1820s and 1850s
the term osteoporosis
was coined to indicate the
pathological appearance of bone
when it had lost bone
volume and bone structure.
Sir Astley Cooper documented
the most frequent fracture
associated with osteoporosis
in those days, hip fracture.
He showed that it was more
common in women than men
and he showed that it increased
in frequency with age.
But our real understanding
of osteoporosis
stems from research undertaken
over the last 75 years,
and principally since 1990, when we
have developed a uniform definition
of osteoporosis based on
bone density measurement,
developed a number of
antiresorptive and formation
stimulating therapies
against osteoporosis,
and developed coherent
risk assessment strategies.
1:37
The step change for this was the WHO
definition of osteoporosis, which
is shown in this next slide,
that was coined in 1994
and characterized osteoporotic bone
density as 2.5 standard deviations
or more below the young normal mean.
And it was a disorder
characterized by low bone mass
and microarchitectural
deterioration of bone tissue,
leading to an increased
risk of fracture.