Hello everyone, I am Maitri Y. Shah.
I'm a Postdoctoral Fellow in Dr. George Calin's lab,
at MD Anderson Cancer Center in Houston Texas.
Today, I'll be talking about
the recent advances in the field of non-coding RNAs and cancer,
particularly those in the last two years that
have influenced research and clinical practice.
Integrated use of advanced genome analysis platforms in
recent years by consortiums such as the Human Genome Project and
the Encyclopedia of DNA elements or encode project have revealed that
the transcription and processing of
the human genome yield a diverse catalog of non-coding RNAs.
The protein coding genes occupy less than two percent of the human genome.
These protein coding genes account for approximately one-third of all annotated genes
whereas long and small non-coding RNAs genes together account for 40 percent of the genes.
Considering the ubiquitous presence and diversity,
these non-coding RNAs have attracted a lot of attention in the past decade.
An extensive research has been performed to understand their role
in normal cellular physiological processes as well as human diseases.