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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Antibiotic resistance
- Examples of antibiotics
- Five strategic goals of WHO’s global action plan
- Vaccines can help lower antibiotic resistance
- WHO prioritization of pathogens: overview
- WHO prioritization of pathogens: highest priority
- Tuberculosis is a worldwide killer
- Rationale for TB as highest priority
- Bacillus Calmette-Guérin (BCG) vaccine
- Advantages of BCG
- Disadvantages of BCG
- T-cells critical to immune memory
- Genetic differences between BCG and M. Tuberculosis
- TB vaccine development strategies: rBCG
- TB vaccine development strategies: subunit vaccines as boosters
- Very few vaccine candidates in clinical trials: rBCG30
- Very few vaccine candidates in clinical trials: VPM1002
- WHO prioritization of pathogens: critical priority
- Enterobacteriaceae family
- Klebsiella pneumoniae
- Klebsiella pneumoniae strains
- Drug resistance in Klebsiella
- Vaccine development against Klebsiella
- Klebsiella CPS (1)
- Klebsiella CPS (2)
- Klebsiella LPS
- Vaccine research against LPS and CPS
- Klebsiella: recent success (1)
- Klebsiella: recent success (2)
- WHO prioritization of pathogens: high priority
- Neisseria gonorrhoeae
- Vaccine design is a challenge
- Neisseria gonorrhoeae: recent success
- WHO prioritization of pathogens: medium priority
- Haemophilus influenzae
- Hib glycoconjugate vaccine (1)
- Hib glycoconjugate vaccine (2)
- Vaccine development in Haemophilus influenzae
- Antigen targets in vaccine development
- Conclusions
- Supporting references
- Acknowledgements
Topics Covered
- Overview of antibiotic resistance
- WHO Global Action Plan against resistance
- WHO’s prioritization of pathogens in the research for new antibiotics
- Vaccines to combat antibiotic resistance
- Vaccine development against selected WHO prioritized pathogens
Links
Series:
Categories:
Therapeutic Areas:
External Links
- WHO's Global Action Plan
- Prioritization of Pathogens to Guide Discovery, Research And Development of New Antibiotics for Drug-resistant Bacterial Infections, Including Tuberculosis
- WHO's Antibiotic Resistance Fact Sheet
- CDC's health-care related infections, Organisms
- CDC's Carbapenem-resistant Enterobacteriaceae (CRE)
- CDC's Hib Vaccines
Talk Citation
McCarthy, P. (2021, May 30). Vaccines as a weapon against antibiotic resistance [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/PEKU1390.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Pumtiwitt McCarthy,
I'm an associate professor in the Department of Chemistry
at Morgan State University, and today I'll be
talking to you about vaccines and how they can be
used as a weapon against antibiotic resistance.
0:17
As an overview of my presentation today,
I'll first be talking about antibiotic resistance.
I will then focus on the major World Health Organization pathogenic targets,
with a focus on one species per priority level.
I'll talk about the current vaccines against these species, as well as
some development that's taking place.
At the end I'll provide some conclusions to the presentation.
0:45
Antibiotic resistance is a global problem, and this is
mainly because of the fact that there is an overuse of antibiotics.
Bacteria are continually evolving, to incorporate new ways to weaken the effect of antibiotics.
The World Health Organization has developed
a global action plan to help combat antimicrobial resistance.
1:10
In this slide, I have some chemical structures of a few of
the antibiotics that currently many bacteria have resistance to,
including penicillin, cephalosporins, carbapenems,
as well as fluoroquinolones.
1:30
The five strategic goals of the World Health Organization's global action plan are:
first, to improve awareness and understanding of antimicrobial resistance;
to strengthen knowledge through surveillance and research;
to reduce the incidence of infection;
to optimize the use of antimicrobial agents;
and also to develop the economic case for
sustainable investment, that will take into account the needs
of all countries, and increase investment in new medicines,
diagnostic tools, vaccines and other inventions.
I've highlighted what we'll focus on in this presentation,
which is vaccines, and vaccines can be
very important to reducing the incidence of infection.