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Printable Handouts
Navigable Slide Index
- Introduction
- Overview of lecture: introduction
- Challenges of immune recognition
- Antigen recognition has unique features
- Overview of lecture: key binding concepts
- Affinity
- Kinetics
- Factors affecting affinity
- Affinity & kinetic constants for key immune interactions
- Avidity
- Multivalent high-avidity molecules
- Overview of lecture: measuring binding properties
- Methods for measuring binding properties
- Principles of surface plasmon resonance
- Measuring the affinity constant (1)
- Measuring the affinity constant (2)
- Scatchard plot
- Measuring affinity by SPR: an example
- Measuring the dissociation rate constant
- Measuring the association rate constant
- Example of measuring binding kinetics
- Measuring avidity
- Overview of lecture: cell surface molecules
- Cell surface molecule interactions are distinct
- Consequence of constraint to membranes
- Consequence of mechanical forces
- Consequence of cooperativity
- Cooperative binding example
- CD2/CD48 complex size affects TCR binding
- Conclusions
- Acknowledgments
Topics Covered
- Challenges of immune recognition
- Key binding concepts
- Affinity
- Kinetics
- Avidity
- Measuring binding properties
- Cell surface molecules
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Talk Citation
van der Merwe, A. (2020, November 30). Affinity, avidity and kinetics in immune recognition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 25, 2021, from https://hstalks.com/bs/4458/.Publication History
Financial Disclosures
- Prof. Anton van der Merwe has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Affinity, avidity and kinetics in immune recognition
Published on November 30, 2020
24 min