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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- The liver as an unusual immunologic organ
- Concept: presentation of antigen in the liver tends to minimize immune reactivity
- Immune relevant cell components in the liver: how antigen is presented is critical
- Physiology of the liver is key
- Lymphocytes are also resident in the liver
- MAIT cells
- Chronic Hepatitis
- Hepatitis viruses
- Viral hepatitis pathogenesis
- Replication of HBV
- Hepatitis B virus (DNA virus – but contains RT)
- Hepatitis B virus (resolved)
- Hepatitis B virus (chronic carriage)
- Hepatitis B virus (“High” v “Low” level carrier) (1)
- Hepatitis B virus (“High” v “Low” level carrier) (2)
- Hepatitis B virus: Chronic infection and chronic disease
- Basic biology is similar across infections
- Chronic untreated HBV
- Chronic treated HBV
- Chronic treated HBV – future
- Lessons from other viruses
- Future approaches – cure (n=1)
- Summary: Chronic hepatitis B as an example of immune-mediated liver pathology
- Conclusion
- Thanks
Topics Covered
- Liver immunology and tolerance
- Components of the liver immune system
- Immune-mediated pathology: viral hepatitis
- Hepatitis B virus: chronic infection and chronic disease
- Other immune-mediated pathologies
Links
Series:
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Therapeutic Areas:
Talk Citation
Klenerman, P. (2023, January 31). Immune mechanisms in liver diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/GTLR4044.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is
Paul Klenerman.
I'm a Truelove Professor at
the Nuffield
Department of Medicine
at the University of Oxford,
and I've got a talk on
immune mechanisms
in liver diseases.
0:15
In this talk, I am
going to discuss
first some basic concepts about
liver immunology and
tolerance and why
the liver immune system
is a little bit special.
Then I will talk about some
of the specific components
of the liver immune system.
Then I'm going to talk about
immune mediated pathology,
in particular, viral hepatitis,
focusing on one particular
type hepatitis B,
and mention along the way other
immune mediated pathologies.
0:42
The liver is a
very unusual organ
from a lot of perspectives,
but particularly from
an immunological one.
One really good
example of this is
that Roy Calne in
the 1960s started
to do transplantation
experiments in pigs.
He found that he
could transplant
livers across
transplantation barriers,
for example, the
kidney can only be
transplanted between
animals that share MHC.
Sharing an MHC is essentially
the key barrier that
needs to be overcome
to have successful
transplantation
of a kidney, or a
lung, or a heart.
For a liver, none of this
makes any difference.
You don't need to
have any sharing
of MHC and it's well tolerated.
The other feature of this is
that the pigs can also
tolerate other organs
once they've had a liver.
This was all set out
in some very nice
papers by Roy Calne,
including this one,
Strange English PIGS,
that were published
in the 1960s.