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1. Introduction
2. Talk outline
3. Immune memory - a definition
4. Antibody levels and affinity
5. Immunological memory
6. Affinity increases
7. How to get memory?
8. Frequency is best (?)
9. Memory cells respond much more rapidly
10. Frequency is aided by enhanced function
11. What is a memory cell?
12. Characteristics of memory B cells
13. Memory B cell differentiation
14. Characteristics of memory T cells
15. Memory T cells and expression of CD45 isoforms
16. Memory cells with different homing potentials
17. Memory cells vs. naïve T cells
18. Signals directing development of memory T cells
19. Theories of memory cell differentiation (1)
20. Theories of memory cell differentiation (2)
21. Variations on these themes
22. Theories of memory cell differentiation (1)
23. Theories of memory cell differentiation (2)
24. CD8 T cell differentiation (1)
25. CD8 T cell differentiation (2)
26. B cell differentiation
27. Different types of memory B cell
28. CD4 T cell differentation
29. A Tfh and CD4 T cell MPEC relationship?
30. Memory pool and AICD
31. B cells as decoys in AICD
32. CD4+ T cell memory is impaired without B cells
33. Phase of an immune response
34. Tracking mrmory B cells in vivo
35. Tracking memory T cells using TCR transgenics
36. Clonal expansion of OT-II T cells in vivo
37. MHC class II tetramers
38. Gating analysis for tetramer +ve cells
39. CD4 memory T cell lifespan

Topics Covered

• Definition and function of immunological memory
• Generation of immunological memory
• Characteristics of memory B cells
• Characteristics of memory T cells
• Signals directing development of B and T cells
• Detection of memory cells in vivo

Links

Series:

• The Immune System - key concepts and questions

Categories:

• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 29, 2020

Financial Disclosures

• I have no disclosures or conflicts of interest connected to my talk.