Complement and lupus

Published on January 31, 2018   42 min
My name is Marina Botto. I'm a Professor of Rheumatology at the Imperial College, and I'm interested in the role of the complement in systemic lupus erythematosus.
In these slides, I'm just summarize some of the key points that I would like to cover today. First, I will start with a discussion of the value of measuring complement in lupus, and discuss whether these measurement are clinically helpful. Then I will briefly discuss the paradoxical role of complement in lupus pathogenesis, and highlighting the different role of the C1q and C3. And we'll also mention recent study linking lupus to some genetic polymorphisms in the complement system to demonstrate how complement biology is not just an old story. I would like also to mention the role of anti-C1q antibodies in the context of this disease. Finally, I will close by mentioning the potential role that complement therapy may have in this disease in the future.