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Printable Handouts
Navigable Slide Index
- Introduction
- Why do we age?
- Factors involved in aging
- Oxidative stress and mitochondrial dysfunction (1)
- Oxidative stress and mitochondrial dysfunction (2)
- Metabolism and proliferation
- Effects of caloric restriction in different species
- Telomere shortening
- Telomeres and cellular senescence
- DNA damage and genomic instability
- Epigenetic alterations: DNA methylation
- Replicative senescence
- SASP functions
- Factors evolutionarily conserved that protect against the processes of aging
- Longevity and senescence
- Aging of tissues and organs
- Senescence is a heterogeneous process at cellular level
- Senescence is the net result of distinct paces of aging
- Defining senescence
- Immune system of young individuals
- Immune system of aged individuals
- Bone marrow and hematopoietic stem cells (HSC)
- B cell reduction and aging
- B1 cells are also affected by aging
- Human thymus during aging
- Naïve T cell reduction and aging
- Differentiation and senescence of T cells
- Alterations in T lymphocytes during aging
- Alterations in B lymphocytes during aging
- Alterations in innate immune cells
- Immunosenescence and infections
- Aging is related to poor response to vaccination against SARS-CoV2 (1)
- Aging is related to poor response to vaccination against SARS-CoV2 (2)
- Summary
- Inflammaging
- Frailty and diseases associated with senescence and inflammaging
- Remodeling and healthy aging
- A new paradigm
- Immunological remodeling during aging
- Regulatory T cells and aging
- Remodeling of NK cells
- Frequency of mature NK cells increase during healthy aging
- Immune cells can eliminate senescent cells
- Healthy aging: inflammaging and anti-inflammaging profile
- Aging is associated with a reduction in reduction in gut microbiota diversity
- Immunosenescence is not linear:rhythms of alterations during aging
- Changes in frequencies of lymphocytes
- Anti-aging therapies
- Promoting healthy aging
- Thank you for listening
Topics Covered
- Introduction to aging and cellular senescence
- Processes that contribute to cellular senescence
- Role of cellular senescence in aging
- effects of aging on organs at different paces
- Processes that culminate in Inflammaging and stem cell exhaustion
- Inflammaging, immunosenescence, and age-related disorders
- Immunosenescence affects protective responses to infection and vaccination
- Healthy aging and longevity
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Caetano, A. (2023, February 28). The aging immune system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 10, 2024, from https://doi.org/10.69645/VLVE1512.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
I am Ana Maria Caetano Faria.
I am a professor of immunology
at the Department of
Biochemistry and Immunology
at the Universidade
Federal de Minas Gerais
in Brazil.
The topic today is The
Aging Immune System.
0:18
The first question that
comes to our minds
when discussing aging
is why do we age?
Not all species age.
Bacteria, for instance,
simply divide
and give rise to new bacteria.
In fact, senescence
emerged with reproduction
that separated the soma from
the reproductive cells
and from the new organism.
Some theories have been
proposed to explain senescence
and they all take this finding
into the light of evolution.
Two of these theories
proposed that senescence
was not predicted by evolution.
According to the most
accepted theory,
The Antagonistic Pleiotropy,
aging is the result of
genes that enhance fitness
early in life when natural
selection is stronger
and become detrimental
in older age
when reproductive
activity ceases.
The Disposable Soma Theory
also considers that the
evolutionary value
of additional life
declines after
the organism reaches the
reproductive period.
Programmed theories
proposed that
senescence was
evolutionarily predicted
since limiting the lifespans
of individual members
of a population increases
the probability
that the population
will avoid extinction.
It's also very interesting
that not all species
deteriorate with aging.
Some multicellular organisms,
like hydra for example,
have the ability to regenerate,
keep fertility, and they do
not show signs of aging.