Human NK cells

Published on July 30, 2015   34 min

Other Talks in the Series: Immunotherapy of Cancer

This is the cells we will talk about, the NK cells seen in blood smear. As you can see, they are large granular lymphocytes with granules that are responsible for killing of tumor cells or virus infected cells.
NK cells originate from hematopoietic stem cells and belong to a growing family that we call Innate Lymphoid Cells, ILC, which all derive from an Id2 positive resource. And depending on the cytokine milieu and on the transcription factors that are being activated, these resource can give rise to different group of ILC. NK cells, as you can see in these figures, belong to group one. ILC is those cells which release interferon gamma and have also, at least in the case of NK cells, the ability to kill viral infected cells.