0:00
Hello, my name is
Dr. Patricia Bloom.
I am an Assistant Professor
at the University of Michigan.
Today I'll be talking
with you about
Microbiome therapies to treat
gastrointestinal diseases.
0:16
The key points I want to
address today are that
the microbiome is altered
in many gastrointestinal
diseases and
microbiome therapies may restore
healthy microbiome
function there for
treating some of those
gastrointestinal diseases.
There are many considerations in
the development and testing
of microbiome therapies,
which we'll review today.
The future of this
field points to
personalized microbiome
therapies tailored
to the individual, disease
and microbiome state.
0:56
The microbiome
here is defined as
the indigenous
microbial communities
and the host environment
they inhabit.
The microbiome is
able to influence
many different organ
systems in the body.
As such, it is key to
health as well as disease.
The microbiome does
many things, for
example, produces enzymes.
It is central to
many different
metabolic functions
including carbohydrate,
protein and lipid metabolism.
The microbiome can prevent
pathogen colonization,
influences barrier function,
manufacturers small molecules
with systemic effects,
and can have a central role
in modulating the immune system.
Because of these myriad
effects of the microbiome,
it is key to health and disease.
