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Printable Handouts
Navigable Slide Index
- Introduction
- Section 1: Leishmanias & leishmaniasis
- Leishmaniasis (1)
- Leishmaniasis (2)
- Main Leishmania species
- Cutaneous and visceral leishmaniasis
- Status of endemicity of leishmaniasis
- Life cycle
- Section 2: Intracellularity
- Mechanism of host-cell invasion by Leishmania
- Section 3: Infection
- Transmission
- The involvement of innate immune cells - neutrophils
- The involvement of innate immune cells - DCs
- The involvement of innate immune cells - monocytes
- Key cytokines and the TH1 vs. TH2 balance
- IL-10 is an important regulator of immunity in leishmaniasis
- Protective and pathological anti-leishmanial immune response (1)
- Protective and pathological anti-leishmanial immune response (2)
- Protective and pathological anti-leishmanial immune response (3)
- Immunity to leishmaniasis – further reading
- Section 4: Schistosoma & bilharzia
- Schistosomiasis (bilharzia)
- Distribution of schistosomiasis
- Life cycle
- Immune modulation by Schistosoma
- Infiltrating host territory (1)
- Infiltrating host territory (2)
- Camouflaging of the migrating schistosomula
- Survival of adult worms within the vascular system of the host
- How adult worms evade and use the host immune response
- Journey of the schistosome eggs
- Eggs are metabolically active and highly immunogenic
- Intestinal egg excretion
- Immunopathology
- Major cell populations located within and adjacent to a granuloma
- Outcome of disease dependent on response elicited
- Granuloma histology
- Development of immune response
- Summary – development of immune response
- Chronic infection & hyporesponsiveness
- Immunity to schistosomiasis – further reading
- Thank you!
Topics Covered
- Introduction to leishmaniasis
- Life cycle of Leishmania
- Mechanism of host-cell invasion by Leishmania- Transmission of Leishmania
- The involvement of the immune system in leishmaniasis
- Introduction to schistosomiasis (bilharzia)
- Life cycle and distribution of Schistosoma
- Immune response and immune modulation during infection of Schistosoma
- Chronic infection of Schistosoma
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Talk Citation
Gadelha, C. (2022, September 29). Parasite immunity: Leishmania and Schistosoma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 10, 2024, from https://doi.org/10.69645/KJXO7759.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Catarina Gadelha has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Parasite immunity: Leishmania and Schistosoma
Published on September 29, 2022
30 min
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
Hello again. My name
is Catarina Gadelha.
I'm a reader in
molecular cell biology
at the University of Nottingham.
My research topic is
host-parasite interactions, with
a particular focus on the
cell surface receptors
and ligands that enable
these interactions.
In this part of the lecture,
we will look at leishmaniasis
and schistosomiasis.
0:32
Leishmaniasis is caused by
several species of
the genus Leishmania,
all transmitted between
mammalian hosts
by female sandflies.
Following a period of
incubation, different species
cause different clinical
manifestations ranging
in severity from self-curing
cutaneous lesions to
life-threatening visceral disease.
The outcome, as usual,
is determined by parasite
and host genetics.
1:03
Cutaneous leishmaniasis,
caused by Leishmania major
or L. tropica is usually
limited to an ulcer
that self heals over
several months,
but can also lead to
scarring and disfigurement.
Mucocutaneous
leishmaniasis is caused
by species of the Viannia group:
Leishmania braziliensis
or L. guyanensis.
It is characterized by
destructive lesions
of the nasal septum,
lips, and palate, and it's
caused by a strong
immunopathological response.
Visceral leishmaniasis,
caused by
Leishmania donovani in Asia
and Africa, or Leishmania
infantum in the Mediterranean,
the Middle East, Central Asia,
and Latin America is the most
severe form of the disease.
Usually fatal unless treated.
Post-kala-azar
dermal leishmaniasis
is a skin manifestation that
occurs in otherwise
healthy people
after treatment of
visceral leishmaniasis.
Table one in this publication
of the journal Lancet,