Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Antibody structure
3. Antibodies - nature's pro-drugs
4. Key properties of antibodies relevant to therapy
5. Antibodies are different from conventional drugs
6. Treatment of sarcoma by serotherapy
7. Conclusions from Hericourt and Richet
8. Paul Ehrlich 1854-1915
9. Modes of antibody therapy
10. Problems with polyclonal antisera
11. Making monoclonal antibodies
12. Pros and cons of monoclonal antibodies
13. Antibodies for cell depletion
14. Genetic engineering of antibodies
15. Chimeric antibodies
16. Making chimeric antibodies
17. Effector functions of anti-NP antibodies
18. Humanised antibodies
19. Making humanised antibodies by phage display
20. Making phage antibodies
21. Infection, replication and enrichment
22. Pros and cons of phage antibodies
23. Antibodies from transgenic mice
24. Antibody nomenclature: source
25. Immunogenicity of therapeutic Mabs
26. Immunogenicity
27. Factors influencing the antiglobulin response
28. Some observations
29. Increasing antibody affinity
30. Antibodies for tumour therapy
31. CD20 antigen
32. CD20 and B cell development
33. Phase III trial of rituximab in follicular lymphoma
34. CD20 epitopes
35. Type I and II antibodies
36. Anti-CD20 antibodies
37. Antibodies for immunomodulation
38. Tumour necrosis factor (TNF)
39. Physiology of TNF
40. Phase III trial of infliximab in rheumatoid arthritis
41. Anti-TNF antibodies
42. CD52 antigen
43. CD52 antigen structure
44. Treatment with rat CD52 antibodies
45. Treatment of lymphoma with alemtuzumab
46. Alemtuzumab effectively suppresses relapses
47. Change in disability after alemtuzumab treatment
48. Phase III trial of alemtuzumab in multiple sclerosis
49. Approval of antibodies and fusion proteins
50. Therapeutic antibodies & fusion proteins
51. Thank you

Topics Covered

• Why antibodies are so useful as drugs
• Antibody therapy
• The development of monoclonal antibodies
• Genetic engineering
• The problem of unwanted immunogenicity
• The importance of affinity
• Examples of antibodies for treatment of cancer
• Examples of antibodies for treatment of immunological diseases

Links

Series:

• The Immune System - key concepts and questions

Categories:

• Clinical Medicine
• Immunology
• Pharmaceutical Sciences

Therapeutic Areas:

• Immunology & Inflammation

External Links

• The Antibody Society
• What is biotechnology?

Talk Citation

Hale, G. (2020, October 29). Therapeutic antibodies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 21, 2021, from https://hstalks.com/bs/4433/.

Publication History

• Published on October 29, 2020

Financial Disclosures

• Dr. Geoffrey Hale has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.