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Printable Handouts
Navigable Slide Index
- Introduction
- Cancer - a disease of cells
- Cell division
- In fact, in the past minute….
- Cell division is normally tightly controlled
- The hallmarks of cancer
- Cancer is regulated by the immune system
- Immune surveillance
- The hallmarks of cancer include immunoevasion
- Evidence for immunosurveillance
- Evidence of anti-tumour T-cell responses
- NGS evidence of anti-tumour immunity
- How do T-cells recognise cancer cells? (1)
- How do T-cells recognise cancer cells? (2)
- Tumour neoantigens
- Tumour antigens lead to a cycle of immune attack
- Evasion of tumour immunity
- NGS evidence for evasion of tumour immunity
- Immune escape
- Immune suppression (1)
- Immune suppresion (2)
- Summary
- Thank you
Topics Covered
- Function and regulation of cell division
- The hallmarks of cancer
- Immune surveillance
- Evidence of anti-tumour T-cell responses
- T cell recognition of cancer cells
- Evasion of tumour immunity
- Immune escape
- Immune suppression
Links
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External Links
Talk Citation
Elliott, T. (2021, September 30). Cancer immunology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/DNZA3079.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Tim Elliott has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Molecular Basis of Cancer
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
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0:00
Hello, my name is Tim Elliot,
I'm the Kidani Professor of Immuno-oncology,
and I work at the University of Oxford in the UK.
This lecture is a basic introduction to the principles of cancer immunology.
0:14
First, some basics on the disease of cancer,
which is a disease of cells.
Now, the average adult human being is composed of around 100 million million cells,
and most of these are differentiated to perform a specific function.
Nerve cells, for example, conduct electrochemical impulses.
Red blood cells transport oxygen around the body and so on.
0:38
They arise through a process of cell division,
and this is a normal homeostatic process that's highly
controlled and it's required for a number of normal processes in life.
First of all, of course, growth.
We all start off as a single cell,
but end up as a collection of 10 to the 14 highly differentiated cells as I just said.
We need cell division also to repair wounds following
some physical damage and just the normal process of homeostasis.
Replacing old cells as they wear out and need replacing also
requires turnover of cells through a process of cell division.
1:18
Just to give you some idea of the scale of that whole process,
in the past minute, our bodies made around 300 million new red blood cells,
12,000 million new gut cells,
and 40,000 new skin cells,
and the old ones are being either recycled or in the case of skin cells,
floated off into the air surrounding you.
Cell division is an ongoing process and we're very busy replacing cells all the time.
Now, cell division is normally very tightly controlled