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Printable Handouts
Navigable Slide Index
- Introduction
- B cells in autoimmune diseases
- B cell development
- Histopathology
- B cell tolerance checkpoints in autoimmune disease
- B cell activating factor (BAFF) (1)
- B cell activating factor (BAFF) (2)
- B cell activating factor (BAFF) (3)
- CD40/CD40L (1)
- CD40/CD40L (2)
- Toll-like receptors (1)
- Toll-like receptors (2)
- Toll-like receptors (3)
- CD19
- Thymic B cells (1)
- Thymic B cells (2)
- Histopathology of B cells in autoimmune diseases
- Tissue-infiltrating B cells (1)
- Tissue-infiltrating B cells (2)
- Tissue-infiltrating B cells (3)
- Antibody-dependent B cell functions in autoimmune diseases (1)
- Antibody-dependent B cell function
- Antibody-dependent B cell function (IgG) (1)
- Antibody-dependent B cell function (IgG) (2)
- Antibody-dependent B cell function (IgG) (3)
- Antibody-dependent B cell function (IgM)
- Antibody-dependent B cell function (Mem B)
- Antibody-dependent B cell functions in autoimmune diseases (2)
- Antigen presentation
- Cytokine production
- Lymphotoxin
- IL-6 (1)
- IL-6 (2)
- IL-6 (3)
- GM-CSF (1)
- GM-CSF (2)
- Interferon gamma (1)
- Interferon gamma (2)
- Regulatory B cells (1)
- Regulatory B cells: subsets of B cells (1)
- Regulatory B cells: subsets of B cells (2)
- Regulatory B cells (2)
- Regulatory B cells: IL10 production and disease progression
- Regulatory B cells: drug screening
- Regulatory B cells: IL-35-producing B cells
- Regulatory B cells: IL-21-producing B cells
- Targeting B cells in autoimmune diseases
- B cell depletion therapy (1)
- B cell depletion therapy (2)
- B cell depletion therapy (3)
- Immune checkpoints therapy (1)
- Immune checkpoints therapy (2)
- Immune checkpoints therapy (3)
- Acknowledgements
Topics Covered
- B cell development
- B cells in autoimmune diseases
- BAFF
- CD40
- Thymic B cells
- Antibody-dependent B cell functions
- Antigen presentation
- Cytokine production
- IL6
- Regulatory B cells
- B cell depletion therapy
- Immune checkpoints therapy
Links
Series:
- The Immune System - Key Concepts and Questions
- Periodic Reports: Advances in Clinical Interventions and Research Platforms
Categories:
Therapeutic Areas:
Talk Citation
Lin, X. (2023, October 31). B cells at the crossroads of autoimmune diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/ZJEE7936.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Xiang Lin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms
Transcript
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0:00
Hello everyone, I'm Lin Xiang
from the School of
Chinese Medicine,
the University of Hong Kong.
Today, I'd like to
talk about the role of
B cells in autoimmune diseases.
0:13
The simplified immune response
against autoantigens.
The B cells receive
the stimulants via
the B cell receptor,
they then present then
antigens to cognate T cells
and further promote
T cell differentiation by
costimulatory molecules
and cytokine production.
Well, these B cells, however,
mature into autoantibody-producing
plasma cells.
This cascade happens throughout
the disease progression.
Now, extensive studies
have suggested
a central role of B cells in
the autoimmune pathogenesis.
Because loss of B cell tolerance
can result in increased
serum levels of
autoantibodies and enhanced
effector T cell response and
tissue damage in patients.
Today we'll walk
through the overview of
these regulated B cell responses
in the development
of autoimmunity.
1:03
As you can see, the
B cell tolerance
is established throughout
the B cell
developmental stages in
both bone marrow and the
peripheral lymphoid organs.
From the prob-B to
pre-B cell stages,
they will migrate
into the periphery
and then become
immature B cells,
through to the maturation and
the differentiation stages,
while part of the plasma
cells will migrate back to
the bone marrow
through chemotaxis.
Although approximately
55% to 75% of early
immature B cells will
exhibit self-reactivity,
most of the other
reactive B cells are
eliminated by multiple
checkpoints accordingly,
which we will explain
in later slides.
Histopathologically, the
massive B cells are detected in