B cells at the crossroads of autoimmune diseases

Published on October 31, 2023   42 min

Other Talks in the Series: The Immune System - Key Concepts and Questions

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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Hello everyone. I'm Lin Xiang from School of Chinese Medicine, the University of Hong Kong. Today I'd like to talk about the roles of B cells in the auto immune diseases.
The simplified immune response against auto antigens. The B cells receive the stimulants, via B cell receptor, present antigen to cognate T cells and then further promote the T cell differentiation by costimulatory molecules and the cytokine production. Well, these B cells, however, mature into auto antibody producing plasma cells. This cascade happens through the disease progression. Now, extensive studies have suggested a central role of B cells in the auto immune pathogenesis. Because loss of B cell tolerance can result in increased serious levels of auto antibodies and enhanced effective T cell response and tissue damages in patients. Today we'll walk through the overview of these regulated B cell responses in the development of auto immunity.
As you can see, the B cell tolerance is established throughout the B cell developmental stages in both bone marrow and the peripheral ligand organs, from the prob-B, pre-B cell stages and then they will migrate into the periphery, and then become immature B cells. Through the maturation and the differentiation stages, while part of the plasma cell will migrate back to the bone marrow through chemotaxis. Although approximately 55-75 percent early immature B cells will exhibit self reactivity, most of the other reactive B cells are eliminated by multiple checkpoints accordingly, which we will explain in later slides. Histopathologically, the massive B cells are detected in

B cells at the crossroads of autoimmune diseases

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