This is part three of my talk. My name is Lucio Luzzatto, I'm a hematologist at the Muhimbili University of Health and Applied Sciences in Dar-es-Salaam, Tanzania.
The notion that by blocking complement, you could avoid hemolysis PNH is not a new concept. But of course we didn't have the technology until the technology of monoclonal antibodies was introduced. So, can we take advantage of this to treat these patients?
So this for a hematologist, are the very many aspects of the clinical burden of PNH. Not only there is anemia, but there is risk of thrombosis, there is the risk of annal depletion through into intravascular hemolysis causing abdominal pain. It can also cause dysphagia, pulmonary hypertension, erectile dysfunction, and multiple problems in pregnancy. So, many of these are complicated in an indirect way, but they all stem from the basic process which I have illustrated.

Complement in PNH and other hemolytic anaemias 3

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