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This is part two of my talk. My name is Lucio Luzzatto, I'm a haematologist at the Muhimbili University of Health and Applied Sciences in Dar-es-Salaam, Tanzania.
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Now, I will come to when the regulation is defective due to a genetic defect. But as you know very well, there are two types of genetics. What we call the classic genetics of inherited disorders which are transmitted through the germline and therefore like those that I've just described, but there is another genetics what we call the somatic cell genetics because mutations can be acquired. These will not affect the progeny but they can very much affect the individual in which they take place. Somatic mutations are of course the essential bases of neoplastic disorders. All tumors are due to somatic mutations. But this disease I'm going to talk about is quite interesting because it's not a cure. And in fact, it was one of the first diseases in which its somatic mutation was recognized as the basis.
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Complement in PNH and other hemolytic anaemias 2

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