My name is Matthew Pickering and I am a Welcome Trust Senior Fellow in Clinical Science
based at the Center for Complements and
Inflammation Research at Imperial College, London.
And the subject of my talk is C3 glomerulopathy.
C3 glomerulopathy is a term used to describe
a group of kidney diseases characterized by
abnormal amounts of complement C3 within the kidney.
It is a new disease classification first proposed in
this paper in 2010 written by myself, Dr. Fakhouri,
professor of renal medicine in Nantes,
two renal pathologists Laure-Helene Noel and
Terence Cook and a complement biologist, Veronique Fremeaux-Bacchi.
The talk will cover the definition of C3 glomerulopathy,
its pathogenesis, lessons from animal models and therapeutic considerations.
When I refer to published data,
you will see the relevant references at the bottom of the slides.
So, let us start with what is C3 glomerulopathy.