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1. Introduction
2. Learning objectives
3. Complement evolution
4. The 'classic' view of complement
5. Complement activation pathways
6. Complement deficiencies lead to infections
7. Revised view of complement
8. Complement deficiencies & autoimmune disease
9. Complement's impact on adaptive immunity
10. Complement recognizes and removes 'threats'
11. Complement receptors act as sensors & effectors
12. Complement receptors activate immune cells
13. Complement-mediated indirect activation of T cells
14. Complement and human Th1 biology
15. CD46: structure and function
16. The lack of an in-vivo model for CD46 research
17. CD46-signaling requirements
18. Th1 induction/contraction is CD46/IL-2 dependent
19. CD46 and IL-2 regulate the 'Th1 life cycle'
20. CD46-deficient T cells & Th1 responses
21. CD46 deficient patients
22. CD46/C3 dysregulation contributes to disease
23. Th1 induction: mice vs. humans
24. C5aR1 & C3aR1 role in T cell responses
25. Impact of anaphylatoxin receptors on CD4+ T cells
26. Impact of complement receptors on CD4+ T cells
27. Complement and CD8+ T cells
28. Evidence for intracellular complement activation
29. Signaling pathways driven by CD46/IL-2R
30. Inside-in versus outside-in signaling
31. The implications of intracellular C3 activation
32. CD46 co-stimulation during CD4+ T cell activation
33. Cell metabolism in immune biology
34. What about C5?
35. C5-NLRP3 inflammasome & normal Th1 induction
36. ‘Normal’ Th1 cells have a NLRP3 signature
37. NLRP3 inflammasome activation
38. Th1 immunity requires inflammasome activity
39. The ‘Complosome’ regulates Th1 responses
40. Intracellular/autocrine systems in cell metabolism
41. Intracellular complosome-driven pathways
42. Summary
43. Acknowledgements

Topics Covered

• Complement in the regulation of general immune cell activity
• Indirect (APC-mediated) effects of complement on T cell activation
• Direct effects of complement on T cell responses
• Role of autocrine and intracellular complement (the Complosome) in Th1 responses
• Crosstalk between the NLRP3 inflammasome and the Complosome
• Regulation of cell metabolism by intracellular/autocrine complement

Links

Series:

• The Complement System

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Kemper, C. (2017, August 31). Complement and T cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 21, 2017, from https://hstalks.com/bs/3578/.

Talk Information

• Published on August 31, 2017