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Hello, everybody. My name is Claudia Kemper.I'm a Senior Investigator and the Chief ofthe Complement and Inflammation Research section at the National Heart,Lung and Blood Institute at the National Institutes of Health in Bethesda,Maryland, the United States.Today, I will tell you a little bit about Complement and T cells.After my lecture, you should know now the direct and indirect impact of complement onT cell responses and the importance of circulating versus immune cell-derived complement.
So, the learning objectives for my lecture todayare that you understand the direct and indirect impact thatcomplement can have on T cell responses and alsothe importance of circulating versus immune cell-derived complement.
So, complement has evolved froma serum effector system to an autocrine functioning system.And, surprisingly, recent data indicate that this systemalso works intracellularly and has been coined, 'the complosome'.
When people hear the word complement,usually certain ideas pop into their mind.One is that they remember that the key effector molecules of complement are C3 and C5,and that complement is an ingrained part of innate immunity.Also, complement is strongly pro-inflammatory.It is the key mediator of the inflammatory reaction.People remember that complement is liver-derived and serum-effective,and people believe that complement is exploredand probably most think it's actually slightly boring.