Subversion of complement by bacteria

Published on October 31, 2017   31 min
Hello, I'm Seppo Meri from the University of Helsinki. And in this presentation, I will discuss how pathogenic bacteria can escape complement mediated killing.
So, the complement system is part of innate immunity; It is involved in interactions with leukocytes, cells of the immune system, and the complement system, with all its recognition molecules, will recognise microbes or other invaders into the human body. It's also involved in the clearance of debris and other material from injured or apoptotic cells. After binding of complement proteins to the microbes, they are recognised by complement receptors, for example, on neutrophils, on macrophages, and that can lead to phagocytosis of the bacteria. Complement activation also generates inflammation that then attracts leukocytes to the area of inflammation. Complement activation is also involved in the capture of antigens for the specific adaptive immune response activation. Antigens will be presented by dendritic cells and macrophages, and B-cells to T-cells, and part of the antigen capture is mediated also by complement receptors.