HLA class I antigen defects in malignant cells - functional and clinical relevance

Published on June 30, 2015   23 min

Other Talks in the Series: Immunotherapy of Cancer

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I am Soldano Ferrone and I hold a faculty position at the Massachusetts General Hospital, Harvard Medical School in Boston, Massachusetts, United States. My research interest in the area of human immunology and especially in the mechanisms which are utilized by tumor cells in order to
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escape recognition and destruction by the host immune system. Over the years, I have investigated how tumor cells change in the expression of HLA class I and class II antigens and how these changes have an impact on the interaction of tumor cells with the host immune system, and as a result, on the clinical course of the disease and on the response to immunotherapeutic strategies. Now today, I would like to discuss with you the changes which have been identified in the expression and function of HLA class I antigen processing machinery in malignant cells. As you know in man like in other animal species, when cells undergo malignant transformation, a number of changes occur,
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HLA class I antigen defects in malignant cells - functional and clinical relevance

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