I am Soldano Ferrone and I hold a faculty position at the Massachusetts General Hospital,
Harvard Medical School in Boston, Massachusetts, United States.
My research interest in the area of
human immunology and especially in the mechanisms which
are utilized by tumor cells in order to
escape recognition and destruction by the host immune system.
Over the years, I have investigated
how tumor cells change in the expression of HLA class I and class II antigens
and how these changes have an impact on
the interaction of tumor cells with the host immune system,
and as a result,
on the clinical course of the disease and on
the response to immunotherapeutic strategies.
Now today, I would like to discuss with you the changes which have been identified in
the expression and function of HLA class I antigen
processing machinery in malignant cells.
As you know in man like in other animal species,
when cells undergo malignant transformation,
a number of changes occur,