I am Soldano Ferrone,
I hold the faculty position
at the Massachusetts General Hospital,
Harvard Medical School, in Boston,
Massachusetts, United States.
My research interest is in
the area of tumor immunology.
And especially in the mechanisms,
which are utilized by tumor cells
in order to escape
recognition and destruction
by the host immune system.
Over the years, I have
investigated how tumor cells change
in the expression of HLA
class I and class II antigens,
and how these changes have an
impact on the direction
of tumor cells with host immune systems.
And as a result on the
clinical course of the disease,
and on the response to
Now today sounds right to discuss
with you the changes
which have been identified in the expression and function
of HLA class I antigen processing machinery
in malignant cells.
And as you know, in man, like in other animal species
when cells undergo malignant transformation