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Other Talks in the Series: Immunotherapy of Cancer

Other Talks in the Series: Vaccines

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We now will discuss in more detail, cancers caused by human papilloma virus. Here you see, the uterus of a patient and a vagina and the cervix, where this virus strikes to establish itself first in a persistent infection. And after many years the virus can cause premalignant lesions. And after a couple more years, you then develop cancer. In the middle you see the virus. And the yellow structure on this virus indicates the L1 protein. And vaccinating against the L1 protein folded as a virus-like particle induces neutralizing antibodies that are characteristic for the two preventive vaccines that are currently marketed, Cervarix and Guardasil.