Schoenfeld, J. (2023, June 29). Immunotherapy and radiation for head and neck cancers [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved February 25, 2024, from https://hstalks.com/bs/5322/.
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Published on June 29, 2023
Research support paid to the institution: Merck, BMS, Regeneron, Debiopharm, EMD Serono Consulting / Scientific Advisory Board / Travel fees: Castle Biosciences, Genentech, Immunitas, Debiopharm, BMS, Tilos, AstraZeneca, ACI Clinical, Astellas, Stimit, Merck KGA, SIRPant, EMD Serono. Stock options: Immunitas.
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My name is Jonathan Schoenfeld.I'm an Associate Professor ofRadiation Oncology at
Harvard Medical School anda senior physician in
Radiation Oncology atthe Dana-Farber Brigham
and Women's Cancer Center.It's a privilege to speak aboutimmunotherapy and radiation
for head-neck cancers.
Here are my relevant
For those who are not familiar
head-neck cancers occur atdifferent sub-sites with some ofthe major sub-sites
including the nasopharynx,oropharynx, oral cavity,hypopharynx, and larynx.These regions are very
important functionally,for speaking, swallowing
and breathing.Functional importance
makes treatment ofhead-neck cancers complex
and patients withhead-neck cancers typically havea multi-modality evaluation toconsider treatment options
including surgery,radiation, and systemic
treatments to besttreat the cancer whileminimizing effects
on quality of life.In addition to the
different sub-sitesand types of treatments,there are also different
types of tumors.This talk focuses on
the most common type oftumor in the head and neck
squamous cell carcinomas.Although the concepts that
I'll discuss apply tosome of the other common typesof head and neck tumors as well.
Among squamous cell carcinomas,there are generally
considered to betwo biologically
different types.The first is the more
traditional typeof head and neck
cancer caused bytobacco and alcohol use thatleads to progressive
genomic changes over time.That causes head and
neck malignancies.The second type of squamous
cell carcinomas arehead and neck tumors
that are related tothe human papilloma
virus or HPV.HPV is a common infection thatimpacts epithelial cells andparticularly the cells among
the lymphoid tissue andthe base of tongue and tonsils
within the oropharynx.As shown, chronic HPV
infection can lead toHPV integration into
the host DNA or intothe nucleus and give rise
to the expression ofthe E6 and E7
oncoprotein that inturn inhibit tumor
suppressors p53 and RB.Over a period of
likely many years oreven decades expression of
the E6 and E7 proteins andsubsequent inhibition
of p53 and RB leads toprogressive genomic changes andthe formation of HPV
associated cancers.The number of HPV associatedoropharyngeal cancers
is significant,peaking among men aged50 and older andincreasing in many
countries around the world.