Immune checkpoint blockade in melanoma

Published on February 28, 2017   51 min

Other Talks in the Series: Immunotherapy of Cancer

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Hello, my name is Elizabeth Buchbinder, and I'm a physician within the Melanoma Disease Center at Dana-Farber Cancer Institute, and an instructor at Harvard Medical School. And today, I'm going to be talking about Immune Checkpoint Blockade in Melanoma.
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Immunotherapy has really been in the news a lot in the last few years, in terms of the amazing advances that have been seen in the treatment of cancer through the use of immunotherapy. However, some of the earliest efforts to use the immune system to battle against cancer, where in the early 1900s, when Dr. Coley, surgeon at the time, discovered that some of his patients who developed post-operative wound infections had subsequent responses in their tumors and shrinkage of their cancer. And he attempted to use this to elicit immune responses in patients by causing infections in their wound and their cancer. He had some success, however, in the end it was not something that caught on, given the fact that, many patients got very sick related to these infections. However, throughout time, there have been spontaneous regressions of cancer and some felt that a lot of these are related to the immune system's function and immune regulation of malignancy.