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Programmed cell death
Published on August 29, 2021 30 min
Other Talks in the Series: The Molecular Basis of Cancer
The molecular basis of cancer metastasis: multi-step metastasis process and anti-metastasis therapeutic development
- Prof. Jing Yang
- University of California San Diego, USA
Virology and cancer biology: the retroviruses and the discovery of oncogenes
- Prof. Lynn W. Enquist
- Princeton University, USA
My name is Xuejun Jiang. I am a Member and Professor at the cell biology program of Memorial Sloan Kettering Cancer Center, in New York City. Today, I will give you a brief overview about a set of cellular processes known as 'programmed cell death'. My lecture will be given in a way from which you might appreciate, from a historical point of view, how some of the important concepts in the field were originated, and how they were established experimentally. We will also briefly discuss the implication of programmed cell death in human diseases, particularly cancer.
Before I start, I need to make some disclaimers. First, this lecture is not for experts on cell death research, but for those who have a general background of biomedical sciences, and want to gain a rudimentary understanding of cell death. Second, I'm not able, or qualified, to cover all important topics in the field of cell death, but my choice of what to include or what is important and interesting is obviously very subjective and biased. Lastly, some of the information or theories we discuss today are still under debate currently, and may even be proven to be wrong in the future, because our understanding of programmed cell death is rapidly evolving. But this is the nature of science, ever evolving, and self-correcting. Now let's get started, by first looking at some numbers.