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Endothelial cells: regulators of autoimmune-neuroinflammation

Published on October 31, 2024   26 min

Other Talks in the Series: The Immune System - Key Concepts and Questions

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Hello, everyone. I'm Dr. Laure Garnier, a Senior Postdoc in Professor Stephanie Hugues' Lab in Geneva in Switzerland. Today, I will talk about the role of endothelial cells as regulators of autoimmune neuroinflammation.
0:18
This lecture will be divided into different points. I will introduce what is the central nervous system, I will call it CNS, the endothelial cells, and neuroinflammation with a special focus on multiple sclerosis and its animal models, the experimental autoimmune encephalomyelitis, or EAE. Then, I will detail what the function of endothelial cells from the blood-brain barrier is, the meninges, and the cribriform plate in neuroinflammation and more particularly, in EAE.
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For the introduction part, the central nervous system,
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which I said, I will call the CNS, consists of the brain and the spinal cord. It receives, processes, and responds to information from the body. The CNS has been traditionally considered an immunologically ignored organ lacking immunosurveillance.
1:20
This dogma has evolved and now current knowledge is that the CNS borders that comprise the blood-brain barrier or BBB, the blood-cerebrospinal fluid barrier or BCSFB, and the blood meningeal barrier, BMB, control immunoregulation to maintain neural homeostasis and tolerance to CNS antigen and to prevent neuroinflammation and resolve damages. Those barriers are composed of endothelial cells so the cells we are interested in this topic are, epithelial cells, pericytes, and astrocytes. The anatomic location of the CNS immune responses tightly controls immune cell migration and entry to the central nervous system parenchyma where neurons are located.

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Endothelial cells: regulators of autoimmune-neuroinflammation

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