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Regulated cell death mechanisms and their crosstalk with the immune system 2

Part 2 of 2
Published on July 30, 2020   25 min

Other Talks in the Series: The Immune System - Key Concepts and Questions

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0:00
Hello and welcome. My name is Luis Alberto Baena-Lopez. I'm a research scientist in the University of Oxford. We will revise in this lecture the main regulated forms of cell death and the crosstalk that they have with the immune system.
0:16
Second part of the lecture; interplay between cell death mechanisms and immunity.
0:22
Cell death can be considered an integral part of the immune response that guides both the immune system and the tissue microenvironment to ensure tissue homeostasis, tissue repair, and the fight against pathogens. Therefore, failure of the cell death mechanisms can severely compromise multiple features of the immune response. Consequently, since the origin of autoimmune diseases, defects in the defense against pathogens, development of tumors, and neurological disorders. This part of the lecture will provide an overview of the extensive intersection between the cell death mechanisms and the immune system, including each regulation. Also, through a series of selected examples, we will illustrate the impact of cell death defects in the immune response, and how either pathogens or faulty cells can hijack the cell death programs to thrive. We will also show how defects in the activation of cell death programs can lead to generated immune diseases or predisposition to infection. As part of this, finally, we will describe how adequate cell death activation can be exploited to fight against the cancer.
1:27
As described before, cell death can influence many aspects of the immune response, and cell death mechanisms have been shown to regulate the number of immune cells, the response of the immune system against pathogens, an inflammatory process and its resolution. Also, the cell death mechanisms install self-tolerance. Therefore, the way cells die is critical to avoid disposal of self-antigens. Reciprocally, they are key to reveal antigens that alert the immune system about the presence of faulty cells, such as tumors and infected cells. In this part of the lecture, we will review the implication of cell death mechanisms in different aspects of the immune response. I will provide key examples that will illustrate the fundamental role played by the regulated cell death mechanisms during the immune response.

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