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1. Introduction
2. The inflammatory response can be discussed in different-contexts (1)
3. What is the "function" of the inflammatory response?
4. Inflammation as an aspect of innate immunity
5. Types of mechanism that let us survive an infection (1)
6. Innate immunity
7. The acute inflammatory response to an infection – overview
8. Pattern recognition receptors (PRRs)
9. PRRs recognize PAMP (1)
10. PRRs recognize PAMP (2)
11. PRRs recognize PAMP (3)
12. PRRs trigger signaling cascades
13. Endosomal and cytoplasmic TLRs
14. NF-kB target genes involved in inflammation
15. Biosynthesis of eicosanoids from arachidonic acid
16. Leukocyte extravasation and the hallmarks of inflammation
17. Early step in the inflammatory response
18. Key (protein) players in the process of tissue infiltration of inflammatory cells
19. Main steps in the infiltration of inflammatory cells
20. Capture, rolling and adhesion depend on specific adhesion molecules (1)
21. Capture, rolling and adhesion depend on specific adhesion molecules (2)
22. Summary
23. Kinetics of acute inflammation
24. Effectors of inflammation
25. Hallmarks of inflammation (1)
26. Hallmarks of inflammation (2)
27. Effector mechanisms of infiltrated leukocytes in the defense against pathogens
28. Inflammatory cell infiltrate
29. Systemic effects of inflammation: fever and the acute-phase response
30. Infections can cause several systemic effects (1)
31. Infections can cause several systemic effects (2)
32. Inflammatory cytokines activate the hypothalamus-pituitary-adrenal axis
33. Inflammation as a response to injury and the concept of DAMP
34. The inflammatory response can be discussed in different-contexts (2)
35. Inflammation in the absence of infection (sterile inflammation)
36. Inflammation after tissue damage
37. Non-microbial agents can induce inflammation
38. Main damage-associated molecular patterns
39. The NALP3 inflammasome is implicated in the response to DAMPs
40. Resolution of inflammation
41. When injury is repaired, or the noxious agent eliminated, inflammation resolves
42. Inflammation: onset to resolution
43. Resolution of inflammation: switch of arachidonate metabolism towards lipoxins
44. Resolvins
45. Resolution of inflammation: switch of macrophages from M1 to M2 phenotype
46. The role of adaptive immunity in inflammation
47. T helper cells regulate inflammation
48. T helper cell phenotypes
49. B cells can regulate inflammation
50. IIgG binding to FcγR regulates the production of inflammatory cytokines and ROS
51. FcγRs are pro- and anti-inflammatory
52. IgG glycosylation patterns
53. Resolution of inflammation: chronic inflammation
54. The inflammatory response can be discussed in different-contexts (3)
55. Inflammation in pathogenesis
56. Chronic inflammation is not just about duration
57. ADifferences between acute and chronic inflammation
58. Hallmarks of inflammation
59. Types of mechanism that let us survive an infection (2)
60. Types of mechanism that let us survive an infection (3)
61. Thanks for your attention!

Topics Covered

• Inflammation as a component of innate immunity
• Pathogen-Associated Molecular Patterns and their receptors
• Leukocyte infiltration
• The hallmarks of inflammation
• Systemic effects of inflammation and acute-phase response
• Inflammation as a response to injury
• Damage-Associated Molecular Patterns
• Resolution of inflammation
• Regulation of inflammation by adaptive immunity
• Chronic Inflammation

Links

Series:

• The Immune System - Key Concepts and Questions

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Publication History

• Published on April 28, 2022

Financial Disclosures

• Prof. Pietro Ghezzi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.