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The Immune System - Key Concepts and Questions

Launched July 2020 Updated February 2024 97 lectures More in production
Prof. Herman Waldmann
University of Oxford, UK
Summary

Immunology is of fundamental importance in understanding the mechanisms that underpin human physiology and human disease. Moreover, it reflects fundamental concepts in cell biology and how these play out in vivo in all multicellular organisms. The immune system has evolved in response to pathogenic microorganisms - bacteria, viruses, protozoans, helminth... read moreworms and fungi, and these pathogens are constantly evolving in order to evade immune surveillance.

The study of immunology has generated some of the most sophisticated (and successful) medicines ever developed; vaccines, transplanted organs and therapeutic antibodies. Equally importantly, the study of immunology has also led directly to the invention of powerful new technologies to answer specific research questions. Where would we be today without monoclonal antibodies, flow cytometry, ELISA, or pregnancy tests?

The aim of this series is to support students in their learning of immunology and introduce key concepts and big questions.

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Fundamental aspects (10 Lectures)  

Inflammation and tissue homeostasis
13 min
  • Prof. Herman Waldmann
  • University of Oxford, UK
Introduction to the immune system
43 min
  • Prof. Herman Waldmann
  • University of Oxford, UK
Hematopoiesis: the making of an immune system
51 min
  • Prof. Paul J. Fairchild
  • University of Oxford, UK
Inflammation: purposes, mechanisms and development
47 min
  • Prof. Pietro Ghezzi
  • University of Urbino, Italy
Phagocytosis
22 min
  • Dr. Eileen Uribe-Querol
  • Universidad Nacional Autónoma de México, Mexico
Regulated cell death mechanisms and their crosstalk with the immune system 1
27 min
  • Dr. Luis Alberto Baena-Lopez
  • University of Oxford, UK
Regulated cell death mechanisms and their crosstalk with the immune system 2
25 min
  • Dr. Luis Alberto Baena-Lopez
  • University of Oxford, UK
Lymphoid architecture - the meeting places that spark the body’s immune reactivity: design and dynamics 1
35 min
  • Dr. Simon Hunt
  • University of Oxford, UK
Lymphoid architecture - the meeting places that spark the body’s immune reactivity: design and dynamics 2
30 min
  • Dr. Simon Hunt
  • University of Oxford, UK
Lymphocyte homing: getting lymphocytes to the right place at the right time
62 min
  • Prof. Ann Ager
  • Cardiff University, UK

Innate immunity (3 Lectures)  

Intercellular mediators (6 Lectures)  

Adaptive immunity B cells (11 Lectures)  

Antigen recognition in the immune system
28 min
  • Prof. Herman Waldmann
  • University of Oxford, UK
B cell biology
26 min
  • Prof. Richard Cornall
  • University of Oxford, UK
Antibody structure and function: antibody structure
34 min
  • Dr. Mike Clark
  • University of Cambridge, UK
Antibody structure and function: antibody function
42 min
  • Dr. Mike Clark
  • University of Cambridge, UK
Antibody genes and diversity
60 min
  • Dr. Mike Clark
  • University of Cambridge, UK
In vivo antibody discovery and hybridoma technology
24 min
  • Prof. Dr. Katja Hanack
  • University of Potsdam, Germany
Antibody engineering: beginnings to bispecifics and beyond
35 min
  • Dr. Ian Wilkinson
  • Absolute Antibody, UK
The role of immunoglobulin superfamily domains in interactions of immune cells
32 min
  • Prof. Neil Barclay
  • University of Oxford, UK
The immunobiology of Fc receptors
39 min
  • Prof. Mark Cragg
  • University of Southampton, UK
Immunoreceptors
38 min
  • Prof. Anton van der Merwe
  • University of Oxford, UK
Affinity, avidity and kinetics in immune recognition
24 min
  • Prof. Anton van der Merwe
  • University of Oxford, UK

Adaptive immunity T cells (9 Lectures)  

The importance of the MHC in immunity (5 Lectures)  

Lymphocyte activation (4 Lectures)  

Major cellular partners in immunity (4 Lectures)  

Immunological tolerance and regulation (3 Lectures)  

Translational immunology - immune deficiency (4 Lectures)  

Translational immunology - protection against pathogenic microbes (13 Lectures)  

Immune responses to viruses
45 min
  • Prof. Paul Klenerman
  • University of Oxford, UK
HIV and the immune system
27 min
  • Prof. Quentin Sattentau
  • University of Oxford, UK
COVID-19: the anti-viral immune response
24 min
  • Prof. Danny Altmann
  • Imperial College London, UK
Bacterial immune evasion
36 min
  • Prof. Christoph Tang
  • University of Oxford, UK
The immunology underlying tuberculosis
40 min
  • Prof. Thomas R. Hawn
  • University of Washington, USA
Innate immunity to fungi
32 min
  • Prof. Gordon D. Brown
  • University of Exeter, UK
Parasite immunity: introduction and Plasmodium
35 min
  • Dr. Catarina Gadelha
  • University of Nottingham, UK
Parasite immunity: Leishmania and Schistosoma
30 min
  • Dr. Catarina Gadelha
  • University of Nottingham, UK
Vaccination
32 min
  • Dr. Anita Milicic
  • University of Oxford, UK
The history of vaccines 1
45 min
  • Prof. Emeritus Anthony R. Rees
  • Rees Consulting AB, Sweden
The history of vaccines 2
60 min
  • Prof. Emeritus Anthony R. Rees
  • Rees Consulting AB, Sweden
The history of vaccines 3
72 min
  • Prof. Emeritus Anthony R. Rees
  • Rees Consulting AB, Sweden
The science of vaccine adjuvants
36 min
  • Dr. Derek O'Hagan
  • GSK, USA

Translational immunology - hypersensitivity, autoimmune disease and their management (17 Lectures)  

Hypersensitivity diseases: type 1 hypersensitivity
26 min
  • Prof. Herman Waldmann
  • University of Oxford, UK
Innate lymphoid cells in allergy
41 min
  • Prof. Emeritus Shigeo Koyasu
  • Keio University, Japan
Hypersensitivity diseases: type II-IV hypersensitivity
47 min
  • Prof. Sara Marshall
  • Wellcome Trust, UK
B cells at the crossroads of autoimmune diseases
42 min
  • Dr. Xiang Lin
  • The University of Hong Kong, Hong Kong
Interleukin-17: from clone to clinic
24 min
  • Prof. Leonie Taams
  • King's College London, UK
Autoimmunity and type 1 diabetes
45 min
  • Prof. Emerita Anne Cooke
  • University of Cambridge, UK
What is new in type 1 diabetes?
37 min
  • Prof. Åke Lernmark
  • Lund University, Sweden
Antibodies to control or prevent type 1 diabetes
29 min
  • Dr. Robert Hilbrands
  • Brussels Free University, Belgium
Monoclonal antibodies in haemato-oncology
45 min
  • Prof. Mark Cragg
  • University of Southampton, UK
Therapeutic antibodies
49 min
  • Dr. Geoffrey Hale
  • Chief Executive Officer of mAbsolve Ltd., UK
Neuroimmunometabolism
30 min
  • Prof. Ana Domingos
  • University of Oxford, UK
The immunology of multiple sclerosis
20 min
  • Dr. Joanne Jones
  • University of Cambridge, UK
Understanding myasthenia gravis and advances in its management
38 min
  • Prof. Henry J. Kaminski
  • George Washington University, USA
The immunology underlying rheumatic diseases
25 min
  • Dr. Hussein Al-Mossawi
  • University of Oxford, UK
Modern management of rheumatoid arthritis - with a focus on biologic therapies
40 min
  • Prof. John Isaacs
  • Newcastle University, UK
Complement and lupus
42 min
  • Prof. Marina Botto
  • Imperial College London, UK
Immune mechanisms in liver diseases
38 min
  • Prof. Paul Klenerman
  • University of Oxford, UK

Translational immunology - transplantation immunology (3 Lectures)  

Translational immunology - cancer immunology (5 Lectures)