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Printable Handouts
Navigable Slide Index
- Introduction
- Section 1: The importance of size
- Scale: 10 0m
- Scale: 10 -1m
- Scale: 10 -2m
- Scale: 10 -3m
- Scale: 10 -4m
- Scale: 10 -5m
- Scale: 10 -6m
- Parasites’ strategies of survival – size matters
- Parasites strategies for surviving in the host
- Section 2: Plasmodia & malaria
- Malaria
- Global distribution
- The Plasmodium spp. Lifecycle (1)
- The Plasmodium spp. Lifecycle (2)
- The Plasmodium spp. lifecycle (3)
- Section 3: At bite size
- Skin as branch point
- Section 4: Liver stage
- Entering the liver (1)
- Entering the liver (2)
- Circumsporozoite protein (CSP) liver cell adhesion
- Section 5: Plasmodium molecules that elicit inflammation, and host receptors that respond to these signals
- Innate sensors of Plasmodium PAMPs – liver stage
- Innate sensors of Plasmodium PAMPs – blood stage
- T-cell response to liver-stage infection
- Malaria clinical outcome
- Section 6: Blood-stage infection is responsible for all clinical signs and symptoms
- Merozoites (emerging from the liver) target and invade RBCs
- Plasmodium falciparum in action!
- Merozoites remodel infected RBCs
- Cytoadherence and rosetting are involved in pathogenesis of malaria
- Infected erythrocyte cell surface
- The P. falciparum erythrocyte membrane protein 1 (PfEMP1)
- The P. falciparum repetitive interspersed family of polypeptides (RIFINs)
- Surface proteins lie at the heart of the host-parasite conflict
- Blood-stage infection is responsible for all clinical signs and symptoms
- Section 7: T-cell response in blood-stage infection
- T-cell response in blood-stage infection
- Immunoregulatory network during malaria (1)
- Immunoregulatory network during malaria (2)
- Section 8: Vaccination
- Antibodies could prevent infection, disease or transmission
- Section 9: Antibodies against pre-erythrocytic stage (preventing infection)
- Transmission bottleneck
- Current state of (vaccination) affairs
- Circumsporozoite protein domains and recognition by human mAbs
- Section 10: Antibodies against erythrocytic stage (preventing disease)
- Considerations
- Molecular basis of blood stage inhibition by mAbs
- Potent inhibitory antibodies against P. falciparum
- Conclusion and knowledge wish list
- Immunity to malaria – further reading
- Thank you!
Topics Covered
- Plasmodium falciparum
- Malaria
- Vaccines
- Size and parasites
- Parasitic survival strategies
- Anopheles gambiae
- Plasmodium lifecycle
- Sporozoites
- Merozoites
- Circumsporozoite protein
- Infected red blood cells
- Cytoadherence
- Rosetting
- Monoclonal antibodies
Links
Series:
Categories:
Therapeutic Areas:
External Links
Talk Citation
Gadelha, C. (2022, August 31). Parasite immunity: introduction and Plasmodium [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/BYXI8389.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Catarina Gadelha has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Parasite immunity: introduction and Plasmodium
Published on August 31, 2022
35 min
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is
Catherine Gadelha.
I'm a reader in
Molecular Cell Biology
at the University of Nottingham.
My research topic is
host-parasite interactions,
with a particular focus on
the cell surface receptors
and ligands that enable
these interactions.
In this lecture on
parasite immunity,
which is divided into two parts,
I plan to cover four areas.
First, I will give a
brief overview of scales
across parasites and
why size matters.
Then I will discuss
the immunity to
three major parasitic
diseases of humans.
Malaria, leishmaniasis
and schistosomiasis.
0:48
Taking you on a quick journey
through size and scale,
which are really important
in biological systems.
0:57
I will start at the metre scale
and the parasite I will use
to exemplify this scale
is the cestode Taenia
solium, or pork tapeworm,
which can grow up to
three metres long.
Moving down the scale
an order of magnitude
and fitting the next slide to
this square here at the
bottom right corner.
1:23
I'm moving from the metre
scale to ten centimetres.
We have, for example,
the nematode
Ascaris lumbricoides
or round worm.
This can grow up
to 25 centimetres,
10 times smaller than
the previous cestode,
but still very large.