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Printable Handouts
Navigable Slide Index
- Introduction
- Leukocyte cell surface interactions
- Immunoglobulin superfamily (IgSF) domains
- Immunoglobulin structure
- Leukocyte membrane proteins
- The breakthrough
- The immunoglobulin superfamily expands
- A very common protein domain
- Nomenclature
- IgSF domains
- Heterogeneity in IgSF domains
- Amino acid sequences of IgSF V-set domains (1)
- Amino acid sequences of IgSF V-set domains (2)
- What is the function of IgSF domains?
- CD2 interacts with CD48 with low affinity
- What is the half life of interactions at cell surface?
- Interaction half lives
- Two IgSF domains are common
- The CD2/SLAM family receptors
- How do IgSF domain proteins interact?
- SIRPα and CD47 binding
- The organisation of IgSF domains can differ
- What domain types are found on leukocytes? (1)
- What domain types are found on leukocytes? (2)
- What do proteins with these domains do?
- Leukocyte membrane protein interactions
- Shape and size at the surface
- Carbohydrates as a feature
- Cell surface proteins and IgSF domains are evolving rapidly
- Cell surface proteins and IgSF domains are evolving rapidly
- Why are they evolving so rapidly?
- IgSF domain roles outside the immune system
- Conclusion
- Acknowledgements
Topics Covered
- Immunoglobulin superfamily (IgSF) domains
- Leukocytes
- Immunoglobulin structure
- Leukocyte membrane proteins
- Cell-surface protein interactions
- Shape and size of membrane proteins
- Rapid evolution of membrane proteins
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Talk Citation
Barclay, N. (2020, October 29). The role of immunoglobulin superfamily domains in interactions of immune cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 14, 2024, from https://doi.org/10.69645/TZNR1814.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Neil Barclay has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: The Immune System - Key Concepts and Questions
Transcript
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0:00
The Role of Immunoglobulin Superfamily Domains and Interactions of Immune Cells.
My name is Neil Barclay,
and I've been working at the Sir William Dunn School of Pathology for many years,
and the theme of my work has been,
what happens at the surface of leukocytes,
and one of the most important families of
proteins are those that contain IgG set domains,
and that's going to be the focus of this presentation.
But first we're going to talk a little bit about what leukocytes do and what
are the types of functions we're trying to explain in molecular terms.
0:36
The key thing about leukocytes is that they interact with
lots of different cell surfaces and soluble proteins,
and what they have to do obviously is to be able to see
new pathogens or indeed old ones and respond to them.
But it's much more to it than just recognize them.
You have to get the optimal response,
you want to have the right strength,
you want to have it in the right place,
and at the right time.
You can see just a bite on the leg,
you want very localized response,
whereas with influenza, you have to pull out all the stops.
Some very different responses.
We don't want any side reactions,
auto-immune disease is obviously
a common problem where the immune system doesn't quite get it right,
and ideally you'd like to be prepared for the next infection
and you have a phenomenon of immunological memory.
1:30
What are immunoglobulin superfamily domains?
I'm going to explain a bit about what domains actually are,
I'm going to talk about how they were discovered to give a little bit of
background history into domains and IgSF domains.
What are the particular structural features of these domains?
How do they interact?
How do they carry out their function?
Also I am going to talk a little bit about why they're evolving so fast
and also what do these proteins do outside the immune system.
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