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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Anatomy
- OCT: optical coherence tomography
- Basic principles of OCT
- Properties of OCT
- OCT & (Enhanced Depth Imaging) EDI-OCT
- A fundus image of the retina
- Fluorescein & indocyanine green angiography
- OCT angiography (OCTA)
- OCTA of a normal eye
- OCTA in diagnosis
- Neovascular age-related degeneration
- Handheld & intra-operative OCT
- Fundus photography
- New interventions
- Central serous chorioretinopathy (CSR)
- Pathophysiology clinical presentation
- Treatment for CSR
- Gene therapy: retinopathies
- Leber congenital amaurosis (LCA)
- Conversion of vitamin A to cis-retinol
- Leber congenital amaurosis: gene therapy
- Gene editing
- Leber congenital amaurosis: CRISPR-CAS9
- iPSCs & CRISPR-CAS9 retinitis pigmentosa
- Sorsby fundus dystrophy
- TIMP3
- Sorsby & CRISP-CAS9
- Other treatments for Sorsby fundus dystrophy
- Summary
- References
Topics Covered
- Basic anatomy of the retina
- Current techniques for retinal imaging
- New imaging techniques and their use in diagnosis
- Medical interventions in retinal disease
- Role of genetics in retinal ophthalmology
- New interventions targeting genetic disease including CRISPR-Cas9
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Kaye, R. and Lotery, A. (2017, September 28). Recent advances in diagnosis and interventions in ophthalmology [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/JDOO6531.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Rebecca Kaye has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Prof. Andrew Lotery has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms
Other Talks in the Series: Macular Degeneration
Transcript
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0:00
Hello. My name is Rebecca Kaye.
I'm an Academic Clinical Fellow in Ophthalmology at
The University of Southampton in Professor Andrew Lotery's group.
Today, I will be speaking about Recent Advances in
Diagnosis and New Interventions in Ophthalmology over the last few years.
This is a presentation compiled both by myself and Professor Andrew Lotery,
Professor of Ophthalmology at The University of Southampton.
0:29
To give you an overview,
the first part of the talk will cover basic retinal anatomy,
some of the current imaging techniques available for retinal imaging,
and new imaging techniques and their role in diagnosis.
Then we will talk about some new medical interventions in retinal disease,
the role of genetics in retinal ophthalmology,
and new interventions targeting retinal diseases, including CRISPR-cas9.
0:56
Vision is a highly complex process that requires
the coordinated activity of both the eye and the brain.
For an individual to see,
the initial steps are performed by the retina,
the light sensitive neuronal tissue situated at the back of the eye.
Here, in the first image,
you can see a fundus photograph of the eye
which demonstrates the retina and the optic disc.
Simply put, there are two types of photoreceptors present in the retina, rods and cones.
When light reaches these photoreceptors,
photons are absorbed by a photopigment,
activating a cascade that converts this light signal into an electrochemical signal.
These electrochemical signals are then
transferred through bipolar cells to ganglion cells,
and are finally converted into action potentials that are transmitted to the brain.
The second image shown here is a histological representation of the retina,
demonstrating its various layers.
Given this crucial role of the retina in vision,
the majority of diseases that lead to blindness are
caused by an acquired or inherited degeneration of the retina.
This review will therefore focus on novel diagnostic techniques and
therapeutic interventions for retinal diseases.