Macrophages in AMD

Published on October 31, 2016   18 min
I'm Doctor Chi-Chao Chan. I've been working in NIH in the past 33 years, and I just retired last year. I am a Scientist Emeritus at National Eye Institute, National Institute of Health, United States. I'm also a Visiting Professor, Zhonshan Ophthalmic Center, Sun Yat-sen University in China. I'm presenting to you Macrophages in AMD or age-related macular degeneration.
And you can see that the local inflammation is very important in AMD. This is from Anderson et al, they had a review, now it's six years ago, and showing you the local inflammation including genetic susceptibility, environmental factors, they all get choroid and retina complex in the macular degenerative eye disease. And later, the local inflammation can produce disease drusen, and geographic, or neovascular AMD, of course, complement play very important role. As the eye pathologies are very interesting in inflammatory cell, there's macrophage, microglia, or resident macrophage, and lymphocytes, they're all inflammatory cells. The same type, these inflammatory cells, they can produce many inflammatory factors that include cytokines, chemokines, complement factors, and inflammasomes. So we need to see how the macrophage can be put to the side.