I'm Doctor Chi-Chao Chan.
I've been working in NIH
in the past 33 years,
and I just retired last year.
I am a Scientist Emeritus
at National Eye Institute,
National Institute of Health,
I'm also a Visiting Professor,
Zhonshan Ophthalmic Center,
Sun Yat-sen University in China.
I'm presenting to you Macrophages in AMD
or age-related macular degeneration.
And you can see
that the local inflammation
is very important in AMD.
This is from Anderson et al,
they had a review,
now it's six years ago,
and showing you the local inflammation
including genetic susceptibility,
they all get choroid and retina complex
in the macular degenerative eye disease.
And later, the local inflammation
can produce disease
drusen, and geographic,
or neovascular AMD,
of course, complement
play very important role.
As the eye pathologies
are very interesting
in inflammatory cell,
there's macrophage, microglia,
or resident macrophage, and lymphocytes,
they're all inflammatory cells.
The same type, these inflammatory cells,
they can produce
many inflammatory factors
that include cytokines, chemokines,
complement factors, and inflammasomes.
So we need to see how the macrophage
can be put to the side.