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HIV cure: harnessing innate and adaptive strategies

Published on November 29, 2018   39 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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I am Luis Montaner at the Wistar Institute and the discussion today studies to harness innate and adaptive strategies towards an HIV cure.
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We can start by reviewing the disease process of HIV infection itself to know that in the context of acute infection there is a seeding of HIV virus throughout the body that is signaled by a very high viral load and a sudden CD4 loss. The disease process itself, underlies a period of several years in which there is a steady-state between the amount of virus and the immune system. Now, the amount of the HIV reservoir which we're going to discuss in the future, is thought to be in some respects established in an individual basis through the dynamics of the immune system and the viral infection in a steady-state within the individual where several factors can contribute to the level of viremia that a person will have which in turn is expected to reflect the level of the reservoir once therapy is initiated. Of course, therapy prevents what otherwise would be the rise in viral load with what would be a decrease in CD4 count followed by opportunistic infections and death. Now, the objective of therapy is to prevent this outcome. But the initiation of therapy relative to this immunological decay is also considered to be a factor that will affect the level of the reservoir that one would retain after the initiation of therapy.

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HIV cure: harnessing innate and adaptive strategies

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