Skip to main content
Search

Bone marrow mesenchymal cells 2

Part 2 of 2
Published on November 30, 2025   29 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

Please wait while the transcript is being prepared...
0:00
Hello, there, my name is Arnold Caplan. I'm a professor of biology at Case Western Reserve University, as it says on this slide. I've been asked to talk about bone marrow mesenchymal cells.
0:19
I make the point that MSCs are not stem cells. They're drug stores for injury-specific tissues. Very different concept than a stem cell.
0:34
I'll talk about the therapeutic concepts for how MSCs work at different locations in your body. First of all, the MSCs themselves have a response profile which is genetically wired into these cells.
0:56
This older paper shows the blue MSCs. If you give it information that shows that it's an inflammatory microenvironment, they make anti-inflammatory drugs and cell surface receptors. If you give it signals on the right-hand side— that there are bacteria around, it makes inflammatory cytokines. Those inflammatory cytokines bring cells from the hematopoietic system into that site to eat up all those pesky bacteria. Here's the same cell, two different sets of sensors, two different sets of stimuli, two different hardwire responses which I call immunomodulatory.

Quiz available with full talk access. Request Free Trial or Login.