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Bone marrow mesenchymal cells 1

Part 1 of 2
Published on November 30, 2025   36 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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0:00
Hello there, my name is Arnold Caplan. I am a professor of biology at Case Western Reserve University, as it says on this slide. I've been asked to talk about bone marrow mesenchymal cells.
0:18
The next slide is my obligatory disclosure information, which is that I started a company called Osiris Theapeutics, and I have no association with that company. The university receives royalties from Mesoblast, which purchased the cell-based therapy in 2013 from Osiris, and they provide a royalty to the Case Western Reserve University, which the university very generously shares with me. You can rest assured it's not a big part of my retirement package.
0:56
This is always a problem, especially for those of the people who are in English-speaking countries. There are two pronunciations for the term mesenchyme or mesenchymal or mesenchyme or mesenchyme. This is a very fancy word, and it relates to the middle layer of an embryo. That layer of the embryo gives rise to all the connective tissue, the bones, the cartilage, and interestingly, the blood supply. From a very primitive progenitor cell, it differentiated into your vasculature to the cells associated with your blood vessels, to all of your blood cells, and all of this connective tissue. In addition, the mesenchyme talks to other tissues in the embryo, and it is actually involved in almost every organ in the body. I'll come back to that. You'll see why this is important.

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