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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Global report 2023
- The global burden of TB, latest estimates 2022
- TB incidence continues to increase globally
- Global recovery in reported number of people newly diagnosed with TB
- Narrowing the global gap
- Mycobacteria and M. tuberculosis complex (MTBC)
- Established knowledge: the bug and resistance
- END TB targets on diagnosis
- Diagnosis of pulmonary tuberculosis
- Evolution of TB diagnostics recommended by WHO
- 2024 New consolidated guidelines
- When is it recommended to use tNGS?
- WHO guidance on WGS/tNGS (1)
- WHO guidance on WGS/tNGS (2)
- WHO catalogue of DR mutations in MTBC
- Are smear microscopy culture and pDST still useful?
- Smear microscopy
- Culture based diagnosis
- Methods used for drugs sensitivity
- Do we still need pDST?
Topics Covered
- Global burden of TB
- M. tuberculosis complex (MTBC)
- Evolution of TB diagnostics
- 2024 new consolidated guidelines
- Targeted next generation sequencing (tNGS)
- WHO guidance on tNGS/WGS
- Phenotypic DST vs. genotypic DST
Links
Series:
Categories:
Therapeutic Areas:
External Links
- Slides 3-7- Global Tuberculosis Report 2023
- Slide 12-14- WHO consolidated guidelines on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection
- Slide 12- Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
- Slide 12- WHO launches new guidance on the use of targeted next-generation sequencing tests for the diagnosis of drug-resistant TB and a new sequencing portal
- Slide 12- Technical Report on critical concentrations for drug susceptibility testing of medicines used in the treatment of drug-resistant tuberculosis
- Slide 12- Technical manual for drug susceptibility testing of medicines used in the treatment of tuberculosis
- Slide 15- Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance
- Slide 15- Guidance for the surveillance of drug resistance in tuberculosis
- Slide 15- The use of next-generation sequencing technologies for the detection of mutations associated with drug resistance in Mycobacterium tuberculosis complex: technical guide
- Slide 17- Clockwork
- Slide 22,31- WHO operational handbook on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection
- Slide 26- WHO consolidated guidelines on tuberculosis: module 4: treatment and care
- Slide 28- Consultation on breakpoint changes necessary in conjunction with introducing new definitions of S, I and R in the EUCAST breakpoint Table v 9.0.
- Slide 29- Antimicrobial susceptibility testing of Mycobacteria: EUCAST
- Slide 29- SOP for calibrating surrogate MIC methods for M. tuberculosis against the EUCAST reference MIC method
- Slide 30- BCCM/ITM Mycobacteria Collection
Talk Citation
Cirillo, D. (2025, July 31). Diagnosis of tuberculosis and drug resistant tuberculosis 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 1, 2025, from https://doi.org/10.69645/KLPI6285.Export Citation (RIS)
Publication History
- Published on July 31, 2025
Financial Disclosures
- There are no commercial/financial matters to disclose.
Diagnosis of tuberculosis and drug resistant tuberculosis 1
Published on July 31, 2025
29 min
Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms
Transcript
Please wait while the transcript is being prepared...
0:00
Good morning. My name
is Daniela Cirillo.
I work at the San Raffaele
Scientific Institute in Milano,
where I'm leading a WHO
collaborating center
in tuberculosis
laboratory strengthening.
The topic of today
is the diagnosis of
tuberculosis and
drug-resistant tuberculosis.
0:23
Briefly, my outline will
touch on the introduction
of tuberculosis,
the guidelines for the
diagnosis of tuberculosis
that have been very
recently issued by the WHO,
the role of WGS and the targeted
NGS, and the mechanism of
resistance with
particular attention to
the new drugs, and what
the new perspective
is for the future.
Of course, this presentation
reflects my personal
view, not the view of
the WHO or
any of the organizations
I'm collaborating with.
1:01
The Global Report
2023 underlines
three very important aspects
compared to the past years.
The first one is that there was
a major global recovery in the
number of people diagnosed with TB
and treated in 2022 after two
years of COVID-related disruption.
This started to
reverse or moderate
the damaging impact of
the pandemic on the diagnosis
and treatment of people
with tuberculosis.
However, tuberculosis
remains the world's
second leading cause
of death from a single
infectious agent in 2022.