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Peptide-drug conjugates as therapeutic modality in drug development 2

Part 2 of 2
Published on June 30, 2025   27 min

Other Talks in the Series: Periodic Reports: Advances in Clinical Interventions and Research Platforms

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0:04
On the basis of these studies, which we have performed by the construction of peptide-based fluorescent dyes, peptide-based radionuclides, an idea came into my mind that why don't we convert the chemical nature of the peptide drug to evaluate the efficacy and pharmacological and cytotoxic profile of the same peptide? Because nowadays, nanoparticles, especially metal nanoparticles, are very well synthesized from different researchers, and they have been found to possess very good anticancer activity. Based on this knowledge, we converted our head-to-tail cyclic peptide into self-assembled peptide nanoparticle followed by loading with fluorescent dyes, as well as, in a later study, we will discuss about multifunctional imaging nanoparticles. Upon the construction of self-assembled peptide nanoparticles, we found that the same possible route of these peptide nanoparticles that targets the mitochondria functions in the membrane of mitochondria to release the cytochrome C, and thus activating the caspase-3 enzyme, which leads to the apoptosis of cancer cells.
1:23
Here, we first performed the fabrication of self-assembled peptide nanoparticles for in vitro assessment of cell apoptosis pathways, as well as the in vivo therapeutic efficacy, and observed these structural changes in the peptide nanoparticles. The first step was the conversion of peptide molecule into the peptide nanoparticles, and these peptide nanoparticles are loaded with cyanine 5.5 as a red fluorescence dye. Here in Image B, we can clearly see the formation of peptide self-assembled nanoparticles. They have a size of about 30-35 nanometer. After loading with cyanine 5.5 dye, we observed a very slight increase in the size of peptide nanoparticles.

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Peptide-drug conjugates as therapeutic modality in drug development 2

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